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Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation 期刊论文

编号：

cb51f18e-55d8-4108-afe1-941e2d9494c8
作者：

Cheng, Hao^[1,2];Xuan, Hongwen^[1,2];Green, Christopher D.^[1];Han, Yixing^[1];Sun, Na^[1];Shen, Hongjie^[3,4,5,6];McDermott, Joseph^[1];Bennett, David A.^[7];Lan, Fei(蓝斐)^[3,4,5,6]Han, JingDong J.^[1];
语种：

English
期刊：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ISSN：0027-8424 2018 年 115 卷 29 期 (7611 - 7616) ; JUL 17
收录：
关键词：

inflammation aging brain H3K27ac gene-body acetylation
摘要：

Brain "inflammaging," a low-grade and chronic inflammation, is a major hallmark for aging-related neurodegenerative diseases. Here, by profiling H3K27ac and gene expression patterns in human and mouse brains, we found that age-related up-regulated (Age-Up) and down-regulated (Age-Down) genes have distinct H3K27ac patterns. Although both groups show promoter H3K27ac, the Age-Up genes, enriched for inflammation-related functions, are additionally marked by broad H3K27ac distribution over their gene bodies, which is progressively reduced during aging. Age-related gene expression changes can be predicted by gene-body H3K27ac level. Contrary to the presumed transcription activation function of promoter H3K27ac, we found that broad gene-body hyper H3K27ac suppresses overexpression of inflammaging genes. Altogether, our findings revealed opposite regulations by H3K27ac of Age-Up and Age-Down genes and a mode of broad gene-body H3K27ac in repressing transcription.
推荐引用方式
GB/T 7714：

Cheng Hao,Xuan Hongwen,Green Christopher D., et al. Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation [J].PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2018,115(29):7611-7616.
APA：

Cheng Hao,Xuan Hongwen,Green Christopher D.,Han Yixing,&Han Jing-Dong J..(2018).Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation .PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,115(29):7611-7616.
MLA：

Cheng Hao, et al. "Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation" .PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115,29(2018):7611-7616.

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