microRNAs (miRNAs) are a class of small non-coding RNAs that play important roles in a variety of biological process. It has been reported that dysregulation of miRNA is always associated with cancer progression and development, and miR-378 aberrant expression has been found in some types of cancers. However, the association of miR-378 and glioma has not been evaluated. In this work, we measured the expression of miR-378 in glioma tissues and non-neoplastic brain tissues was measured using real-time PCR, and found that miRNA-378 expression level was significantly lower in glioma tissues compared with non-neoplastic brain tissues. Patients with lower miR-378 expression level had significantly poorer overall survival. Multivariate Cox regression analysis showed that miR-378 expression was an independent prognostic factor for 5-year overall survival. Over-expression of miR-378 inhibits glioma cell migration and invasion. In conclusion, our results indicated that miR-378 may serve as a tumor suppressor and play an important role in inhibiting tumor migration and invasion. Our work implicates the potential effect of miR-378 on the prognosis of glioma.
[1]Wuxi Second Peoples Hosp, Dept Neurosurg, Wuxi 214002, Jiangsu, Peoples R China.
[2]Fudan Univ, Shanghai Canc Ctr, Dept Hepat Surg, Shanghai 200032, Peoples R China.
[3]Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Neurosurg, Shanghai 200092, Peoples R China.
[4]Second Mil Med Univ, Changzheng Hosp, Dept Neurosurg, Shanghai 200003, Peoples R China.
[5]105 Hosp PLA, Dept Neurosurg, Hefei 230000, Anhui, Peoples R China.
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