[1]Renji Hospital, Department of Epidemiology,Shanghai,China
[2]Medical Center of Fudan University, Department of Epidemiology,Shanghai,China
[3]Renji Hospital, SKLORG & Department of Epidemiology,Shanghai,China
[4]University at Buffalo, State University of New York, Department of Biostatistics,Buffalo,United States
[5]Fudan Universit, School of Public Healt,Shanghai,China
[6]Vanderbilt Ingram Cancer Center, Department of Medicine,Nashville,United States
Background: Green tea is one of the most widely consumed beverages in Asia. While a possible protective role of green tea against various chronic diseases has been suggested in experimental studies, evidence from human studies remains controversial. Methods: We conducted this study using data from Shanghai Men"s Health Study (SMHS) and Shanghai Women"s Health Study (SWHS), two population-based prospective cohorts of middle-aged and elderly Chinese adults in urban Shanghai, China. Hazard ratios (HR) and 95% confidence intervals (CI) for risk of all-cause and cause-specific mortality associated with green tea intake were estimated using Cox proportional hazards regression models. Results: During a median follow-up of 8.3 and 14.2 years for men and women, respectively, 6517 (2741 men and 3776 women) deaths were documented. We found that green tea consumption was inversely associated with risk of all-cause mortality (HR 0.95; 95% CI, 0.90-1.01), particularly among neversmokers (HR 0.89; 95% CI, 0.82-0.96). The inverse association with cardiovascular disease (CVD) mortality (HR 0.86; 95% CI, 0.77-0.97) was slightly stronger than that with all-cause mortality. No significant association was observed between green tea intake and cancer mortality (HR 1.01; 95% CI, 0.93-1.10). Conclusions: Green tea consumption may be inversely associated with risk of all-cause and CVD mortality in middle-aged and elderly Chinese adults, especially among never smokers. © 2016 Publishing services by Elsevier B.V. on behalf of The Japan Epidemiological Association.