首页 / 院系成果 / 成果详情页

Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator 期刊论文

编号：

ce13e184-3200-4d8d-9503-a4058a4147b8
作者：

Zhou, Xiang(周祥)^[1,2,4,5]Hao, Qian^[1,2,4];Liao, Peng^[1,2];Luo, Shiwen^[3];Zhang, Minhong^[3];Hu, Guohui^[3];Liu, Hongbing^[1,2];Zhang, Yiwei^[1,2];Cao, Bo^[1,2];Baddoo, Melody^[2];Flemington, Erik K.^[2];Zeng, Shelya X.^[1,2];Lu, Hua^[1,2];
语种：

English
期刊：

ELIFE ISSN：2050-084X 2016 年 5 卷 ; JUN 10
收录：
摘要：

Cancer develops and progresses often by inactivating p53. Here, we unveil nerve growth factor receptor (NGFR, p75NTR or CD271) as a novel p53 inactivator. p53 activates NGFR transcription, whereas NGFR inactivates p53 by promoting its MDM2-mediated ubiquitin-dependent proteolysis and by directly binding to its central DNA binding domain and preventing its DNA-binding activity. Inversely, NGFR ablation activates p53, consequently inducing apoptosis, attenuating survival, and reducing clonogenic capability of cancer cells, as well as sensitizing human cancer cells to chemotherapeutic agents that induce p53 and suppressing mouse xenograft tumor growth. NGFR is highly expressed in human glioblastomas, and its gene is often amplified in breast cancers with wild type p53. Altogether, our results demonstrate that cancers hijack NGFR as an oncogenic inhibitor of p53.
推荐引用方式
GB/T 7714：

Zhou Xiang,Hao Qian,Liao Peng, et al. Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator [J].ELIFE,2016,5.
APA：

Zhou Xiang,Hao Qian,Liao Peng,Luo Shiwen,&Lu Hua.(2016).Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator .ELIFE,5.
MLA：

Zhou Xiang, et al. "Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator" .ELIFE 5(2016).

浏览次数：4  下载次数：0

分享到：

浏览次数：4

下载次数：0

打印次数：0