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Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma 期刊论文

编号：

cfaad9e6-1583-4e79-b8e7-52f55e67174b
作者：

Gong, Hongli^[1];Shi, Yi(石毅)*^[2]Zhou, Xia^[3];Wu, Chunping^[1];Cao, Pengyu^[1];Xu, Chen^[4];Hou, Dongsheng^[4];Wang, Yuezhu^[5];Zhou, Liang(周梁)^[1]
语种：

English
期刊：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY ISSN：0099-2240 2014 年 80 卷 23 期 (7356 - 7363) ; DEC
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摘要：

The compositions and abundances of the microbiota in the ecological niche of the human throat and the possible relationship between the microbiota and laryngeal cancer are poorly understood. To obtain insight into this, we enrolled 27 laryngeal carcinoma patients and 28 subjects with vocal cord polyps as controls. For each subject, we simultaneously collected swab samples from the upper throat near the epiglottis (site I) and tissue samples from the vestibulum laryngis to the subglottic region (site II). The microbiota of the throat were fully characterized by pyrosequencing of barcoded 16S rRNA genes. We found 14 phyla, 20 classes, 38 orders, 85 families, and 218 genera in the throats of enrolled subjects. The main phyla were Firmicutes (54.7%), Fusobacteria (14.8%), Bacteroidetes (12.7%), and Proteobacteria (10.6%). Streptococcus (37.3%), Fusobacterium (11.3%), and Prevotella (10.6%) were identified as the three most predominant genera in the throat. The relative abundances of 23 bacterial genera in site I were significantly different from those in site II (P < 0.05). The relative proportions of 12 genera largely varied between laryngeal cancer patients and control subjects (P < 0.05). Collectively, this study outlined the spatial structure of microbial communities in the human throat. The spatial structure of bacterial communities significantly varied in two anatomical sites of the throat. The bacterial profiles of the throat of laryngeal cancer patients were strongly different from those of control subjects, and several of these microorganisms may be related to laryngeal carcinoma.
推荐引用方式
GB/T 7714：

Gong Hongli,Shi Yi,Zhou Xia, et al. Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma [J].APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2014,80(23):7356-7363.
APA：

Gong Hongli,Shi Yi,Zhou Xia,Wu Chunping,&Zhou Liang.(2014).Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma .APPLIED AND ENVIRONMENTAL MICROBIOLOGY,80(23):7356-7363.
MLA：

Gong Hongli, et al. "Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma" .APPLIED AND ENVIRONMENTAL MICROBIOLOGY 80,23(2014):7356-7363.

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