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Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance 期刊论文

编号：

d0456bb7-c8dc-4682-8ea5-def00d12fe6c
作者：

AlameEmane, A. K.^[1,2] Xu, P.^[3,4] PierreAudigier, C.^[1,5] CadetDaniel, V.^[1] Shen, X.^[6] Sraouia, M.^[5] Siawaya, J. F. Djoba^[2] Takiff, H.^[7] Gao, Q.^[3,4] Gicquel, B.^[1,8]
语种：

English
期刊：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE ISSN：1027-3719 2015 年 19 卷 6 期 (679 - 684) ; JUN
收录：
关键词：

tuberculosis drug resistance pyrazinamide
摘要：

BACKGROUND: Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern. OBJECTIVE: To determine the timing of pncA mutations that confer pyrazinamide (PZA) resistance in relation to mutations conferring resistance to isoniazid (INH) and rifampicin (RMP). DESIGN: Isolates from two major urban centres Paris (101 strains) and Shanghai (171 strains) were investigated for the association of pncA mutations with resistance to drugs other than PZA. RESULTS: The proportion of pncA mutations found in INH-monoresistant strains was not increased. CONCLUSION: pncA mutations associated with PZA resistance were found almost exclusively in MDR-TB strains, underlining the importance of determining PZA resistance when treating MDR- or XDR-TB.
推荐引用方式
GB/T 7714：

Alame-Emane A. K.,Xu P.,Pierre-Audigier C., et al. Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance [J].INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE,2015,19(6):679-684.
APA：

Alame-Emane A. K.,Xu P.,Pierre-Audigier C.,Cadet-Daniel V.,&Gicquel B..(2015).Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance .INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE,19(6):679-684.
MLA：

Alame-Emane A. K., et al. "Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance" .INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 19,6(2015):679-684.

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