首页 / 院系成果 / 成果详情页

Tumor-infiltrating Neutrophils is Prognostic and Predictive for Postoperative Adjuvant Chemotherapy Benefit in Patients With Gastric Cancer 期刊论文

编号：

d0a10fa7-8269-41ed-a1a4-cdf3955fd5df
作者：

Zhang, Heng^[1];Liu, Hao^[1];Shen, Zhenbin(沈振斌)^[1]Lin, Chao(林超)^[1]Wang, Xuefei(汪学非)^[1]Qin, Jing(秦净)^[1]Qin, Xinyu(秦新裕)^[1]Xu, Jiejie^[2];Sun, Yihong(孙益红)^[1]
语种：

English
期刊：

ANNALS OF SURGERY ISSN：0003-4932 2018 年 267 卷 2 期 (311 - 318) ; FEB
收录：
关键词：

adjuvant chemotherapy gastric cancer overall survival prognosis tumor-infiltrating neutrophils
摘要：

Objective: This study was aimed to investigate the prognostic value of tumor-infiltrating neutrophils (TINs) and to generate a predictive model to refine postoperative risk stratification system for patients with gastric cancer. Background: TIN presents in various malignant tumors, but its clinical significance in gastric cancer remains obscure. Methods: The study enrolled 3 independent sets of patients with gastric cancer from 2 institutional medical centers of China. TIN was estimated by immunohistochemical staining of CD66b, and its relationship with clinicopathological features and clinical outcomes were evaluated. Prognostic accuracies were evaluated by C-index and Akaike information criterion. Results: TINs in gastric cancer tissues ranged from 0 to 192cells/high magnification filed (HPF), 0 to 117cells/HPF, and 0 to 142cells/HPF in the training, testing, and validation sets, respectively. TINs were negatively correlated with lymph node classification (P = 0.007, P = 0.041, and P = 0.032, respectively) and tumor stage (P = 0.019, P = 0.013, and P = 0.025, respectively) in the 3 sets. Moreover, multivariate analysis identified TINs and tumor node metastasis (TNM) stage as 2 independent prognostic factors for overall survival. Incorporation of TINs into well-established TNM system generated a predictive model that shows better predictive accuracy for overall survival. More importantly, patients with higher TINs were prone to overall survival benefit from postoperative adjuvant chemotherapy. These results were validated in the independent testing and validation sets. Conclusions: TIN in gastric cancer was identified as an independent prognostic factor, which could be incorporated into standard TNM staging system to refine risk stratification and predict for overall survival benefit from postoperative chemotherapy in patients with gastric cancer.
推荐引用方式
GB/T 7714：

Zhang Heng,Liu Hao,Shen Zhenbin, et al. Tumor-infiltrating Neutrophils is Prognostic and Predictive for Postoperative Adjuvant Chemotherapy Benefit in Patients With Gastric Cancer [J].ANNALS OF SURGERY,2018,267(2):311-318.
APA：

Zhang Heng,Liu Hao,Shen Zhenbin,Lin Chao,&Sun Yihong.(2018).Tumor-infiltrating Neutrophils is Prognostic and Predictive for Postoperative Adjuvant Chemotherapy Benefit in Patients With Gastric Cancer .ANNALS OF SURGERY,267(2):311-318.
MLA：

Zhang Heng, et al. "Tumor-infiltrating Neutrophils is Prognostic and Predictive for Postoperative Adjuvant Chemotherapy Benefit in Patients With Gastric Cancer" .ANNALS OF SURGERY 267,2(2018):311-318.

浏览次数：2  下载次数：0

分享到：

浏览次数：2

下载次数：0

打印次数：0