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Prostate-specific antigen kinetics under androgen deprivation therapy and prostate cancer prognosis 期刊论文

编号：

d0c86a13-470e-4138-a7e7-ac86f723c72d
作者：

Zhang, Limin[0](张立旻)#^[1]Jiang, Haowen[1](姜昊文)*^[2]Tong, Shijun[2](童仕俊)^[1]Zhu, Huiqing[3]^[3];Liu, Jun[4]^[4];Ding, Qiang[5](丁强)^[5]
地址：

[1]Fudan University, Department of Urology,Shanghai,China
[2]Universidad Fudan, Department of Urology,Shanghai,China
[3]Huashan Hospital, Department of Nuclear Medicine,Shanghai,China
[4]Sichuan University, College of Life Sciences,Chengdu,China
[5]Nanjing Medical University, Jiangsu Breast Disease Center,Nanjing,China
Scopus被引频次：

1 次
语种：

英文
期刊：

Urologia Internationalis ISSN：0042-1138 2013 年 91 卷 1 期 (38 - 48)
收录：
关键词：

Androgen deprivation therapy Prognosis Prostate cancer Prostate-specific antigen
摘要：

Objectives: To compare the difference in characteristics of post-treatment prostate-specific antigen (PSA) kinetics among respective patients and their influence on disease prognosis. Methods: A cohort of totally 332 eligible patients with histologically confirmed and hormonally naïve prostate cancer, identified from the patients' database of Huashan Hospital, all received combined androgen deprivation therapy including bilateral orchiectomy or luteinizing hormone-releasing hormone antagonists with the oral administration of flutamide 250 mg t.i.d. All patients had their serum PSA level tested at least every 3 months in the first 2 years and at least once a half year from the third year on. PSA nadir, time to PSA nadir (TTPN), PSA normalization (<4 ng/ml), undetectable PSA level (<0.2 ng/ml), biochemical failure, overall survival and cancer-specific survival were analyzed. Results: PSA normalization, TTPN, and reaching the undetectable PSA level perhaps were the independent risk factors for predicting the three types of prognosis. Probably the best cut-off of PSA nadir was 0.2 ng/ml (sensitivity 65.7%, specificity 80.6%) and the best cut-off of TTPN was 10 months (sensitivity 71.6%, specificity 63.9%). Conclusions: These results implied that a lower level of PSA nadir and longer TTPN can predict a better disease prognosis. Copyright © 2013 S. Karger AG, Basel.
推荐引用方式
GB/T 7714：

Zhang Limin/37066802900[0],Jiang Haowen/24724620000[1],Tong Shijun/37103047700[2], et al. Prostate-specific antigen kinetics under androgen deprivation therapy and prostate cancer prognosis [J].Urologia Internationalis,2013,91(1):38-48.
APA：

Zhang Limin/37066802900[0],Jiang Haowen/24724620000[1],Tong Shijun/37103047700[2],Zhu Huiqing/55763116700[3],&Ding Qiang/7102341288[5].(2013).Prostate-specific antigen kinetics under androgen deprivation therapy and prostate cancer prognosis .Urologia Internationalis,91(1):38-48.
MLA：

Zhang Limin/37066802900[0], et al. "Prostate-specific antigen kinetics under androgen deprivation therapy and prostate cancer prognosis" .Urologia Internationalis 91,1(2013):38-48.

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