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Upregulation of spondin-2 predicts poor survival of colorectal carcinoma patients 期刊论文

编号：

d1a6a525-5ffa-4b07-87f9-387bc1adb718
作者：

Zhang, Qian^[1,2];Wang, XiaoQing^[1,2,3];Wang, Jie^[1,2];Cui, ShuJian^[6];Lou, XiaoMin^[7];Yan, Bing^[8,9];Qiao, Jie^[1,2];Jiang, YingHua(姜英华)^[1,2]Zhang, LiJun(张丽军)^[5]Yang, PengYuan(杨芃原)^[1,2,3]Liu, Feng(刘锋)^[1,2,4]
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2015 年 6 卷 17 期 (15095 - 15110) ; JUN 20
收录：
关键词：

colorectal cancer SPON2 spondin-2 prognosis protein marker
摘要：

Colorectal cancer (CRC) is the third and second most common cancer in males and females worldwide, respectively. Spondin-2 is a conserved secreted extracellular matrix protein and a candidate cancer biomarker. Here we found that Spondin-2 mRNA was upregulated in CRC tissues using quantitative RT-PCR and data-mining of public Oncomine microarray datasets. Spondin-2 protein was increased in CRC tissues, as revealed by immunohistochemistry analyses of two tissue microarrays containing 180 cases. Spondin-2 gene expression was significantly associated with CRC stage, T stage, M stage and Dukes stage, while its protein was associated with age and M stage. Kaplan-Meier analysis revealed that the upregulated Spondin-2 mRNA and protein predicted poor prognosis of CRC patients. Univariate and multivariate Cox regression analyses indicated that grade, recurrence, N stage and high Spondin-2 were independent predictors of overall survival of CRC patients. ELISA revealed that plasma Spondin-2 was upregulated in CRC and dropped after surgery. Receiver operating characteristic curve analysis demonstrated that plasma Spondin-2 has superior predictive performance for CRC with an area under the curve of 0.959 and the best sensitivity/specificity of 100%/90%. Furthermore, ectopic expression of Spondin-2 enhanced colon cancer cell proliferation. Spondin-2 could be an independent diagnostic and prognostic biomarker of colon cancer.
推荐引用方式
GB/T 7714：

Zhang Qian,Wang Xiao-Qing,Wang Jie, et al. Upregulation of spondin-2 predicts poor survival of colorectal carcinoma patients [J].ONCOTARGET,2015,6(17):15095-15110.
APA：

Zhang Qian,Wang Xiao-Qing,Wang Jie,Cui Shu-Jian,&Liu Feng.(2015).Upregulation of spondin-2 predicts poor survival of colorectal carcinoma patients .ONCOTARGET,6(17):15095-15110.
MLA：

Zhang Qian, et al. "Upregulation of spondin-2 predicts poor survival of colorectal carcinoma patients" .ONCOTARGET 6,17(2015):15095-15110.

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