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Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids 期刊论文

编号：

d24d15e5-1ffb-4765-ab9d-aed5142f8abb
作者：

Cai, Mengfei^[1,2,3];Zhang, Wenting^[1,2,3];Weng, Zhongfang^[4,5];Stetler, R. Anne^{[1,2,3,4,5,6]};Jiang, Xiaoyan^[4,5];Shi, Yejie^[4,5,6];Gao, Yanqin(高艳琴)^[1,2,3,4,5]Chen, Jun^{[1,2,3,4,5,6]};
语种：

English
期刊：

AGING AND DISEASE ISSN：2152-5250 2017 年 8 卷 5 期 (531 - 545) ; OCT
收录：
关键词：

docosahexaenoic acid eicosapentaenoic acid angiogenesis neurogenesis white matter restoration
摘要：

The aged population is among the highest at risk for ischemic stroke, yet most stroke patients of advanced ages (>80 years) are excluded from access to thrombolytic treatment by tissue plasminogen activator, the only FDA approved pharmacological therapy for stroke victims. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) robustly alleviate ischemic brain injury in young adult rodents, but have not yet been studied in aged animals. This study investigated whether chronic dietary supplementation of n-3 PUFAs protects aging brain against cerebral ischemia and improves long-term neurological outcomes. Aged (18-month-old) mice were administered n-3 PUFA-enriched fish oil in daily chow for 3 months before and up to 8 weeks after 45 minutes of transient middle cerebral artery occlusion (tMCAO). Sensorimotor outcomes were assessed by cylinder test and corner test up to 35 days and brain repair dynamics evaluated immunohistologically up to 56 days after tMCAO. Mice receiving dietary supplementation of n-3 PUFAs for 3 months showed significant increases in brain ratio of n-3/n-6 PUFA contents, and markedly reduced long-term sensorimotor deficits and chronic ischemic brain tissue loss after tMCAO. Mechanistically, n-3 PUFAs robustly promoted post-ischemic angiogenesis and neurogenesis, and enhanced white matter integrity after tMCAO. The Pearson linear regression analysis revealed that the enhancement of neurogenesis and white matter integrity both correlated positively with improved sensorimotor activities after tMCAO. This study demonstrates that prophylactic dietary supplementation of n-3 PUFAs effectively improves long-term stroke outcomes in aged mice, perhaps by promoting post-stroke brain repair processes such as angiogenesis, neurogenesis, and white matter restoration.
推荐引用方式
GB/T 7714：

Cai Mengfei,Zhang Wenting,Weng Zhongfang, et al. Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids [J].AGING AND DISEASE,2017,8(5):531-545.
APA：

Cai Mengfei,Zhang Wenting,Weng Zhongfang,Stetler R. Anne,&Chen Jun.(2017).Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids .AGING AND DISEASE,8(5):531-545.
MLA：

Cai Mengfei, et al. "Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids" .AGING AND DISEASE 8,5(2017):531-545.

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