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Genome-wide linear B-cell epitopes of enterovirus 71 in a hand, foot and mouth disease (HFMD) population 期刊论文

编号：

d2841cc1-14f6-4abe-a514-25d6e4e9cd2a
作者：

Zhang, Huiying^[1];Song, Zhigang(宋志刚)^[1]Yu, Huiju^[2];Zhang, Xiaoling^[1];Xu, Shanshan^[2];Li, Zhong^[3];Li, Jingzhi^[3];Xu, Hongke^[3];Yuan, Zhenghong(袁正宏)^[4,5]Ma, Hongwei^[3];Yi, Zhigang(易志刚)^[1,4,5]Hu, Yunwen(胡芸文)^[1]
语种：

English
期刊：

JOURNAL OF CLINICAL VIROLOGY ISSN：1386-6532 2018 年 105 卷 (41 - 48) ; AUG
收录：
关键词：

HFMD Enterovirus71 Epitopes Cross-reactive antibody Peptide array
摘要：

Background: Enteroviruses cause hand, foot and mouth disease (HFMD). The host B-cells recognize the viral proteins and provoke humoral responses. Deciphering the B-cell responses to the viral epitopes helps diagnosis and vaccine development. Objectives: The objective of the present study was to investigate for the first time the landscape of genome-wide linear B-cell epitopes of enterovirus 71 in HFMD population. Study design: The peptides encompassing the entire coding region of EV71 were chemically synthesized and displayed on a microarray. The peptide microarray was used to screen serum samples from an HFMD population, including EV71-, CAV10-, CAV16- and CAV6-infected patients. We identified the dominant epitope-containing-peptides (DECPs) that react with the sera of more than 20% of the HFMD population and the common DECPs that cross-react with the sera from other enteroviruses-infected population. Results: Ten DECPs reacting with IgM and 9 DECPs reacting with IgG antibodies were identified, of which, 6 IgM and 5 IgG common DECPs cross-reacted with the sera from other enteroviruses. Some DECPs preferentially reacted with IgG or IgM antibodies and some epitope-antibody interactions correlated with the severity of HFMD. Conclusions: We uncovered the DECPs and the common DECPs among a group of enteroviruses in HFMD population and found that some epitope-antibody reactions were associated with the outcome of HFMD. These data may guide developing vaccines against the enteroviruses and help the diagnosis and prognosis of HFMD.
推荐引用方式
GB/T 7714：

Zhang Huiying,Song Zhigang,Yu Huiju, et al. Genome-wide linear B-cell epitopes of enterovirus 71 in a hand, foot and mouth disease (HFMD) population [J].JOURNAL OF CLINICAL VIROLOGY,2018,105:41-48.
APA：

Zhang Huiying,Song Zhigang,Yu Huiju,Zhang Xiaoling,&Hu Yunwen.(2018).Genome-wide linear B-cell epitopes of enterovirus 71 in a hand, foot and mouth disease (HFMD) population .JOURNAL OF CLINICAL VIROLOGY,105:41-48.
MLA：

Zhang Huiying, et al. "Genome-wide linear B-cell epitopes of enterovirus 71 in a hand, foot and mouth disease (HFMD) population" .JOURNAL OF CLINICAL VIROLOGY 105(2018):41-48.

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