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Paternalethanolexposureandbehavioralabnormitiesinoffspringandassociationwithalterationsinthemethylationofimprintedgenes  会议论文  

  • 编号:
    d2d1082a-7266-4717-8753-c5a9aeb41851
  • 作者:
    Fei Liang;Lei Diao;Jun Liu;Nan Jiang;Jin Zhang;Huijun Wang;Wenhao Zhou;Guoying Huang;Duan Ma
  • 作者单位:
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecula;Children Hospital, Fudan University, 200032, China;
  • 关键词:
    Paternal ethanol exposure;offspring;learning and memory;mood;methylation;imprinted genes;
  • 会议名称:
    中国遗传学会第九次全国会员代表大会暨学术研讨会
  • 会议时间:
  • 会议地点:
    哈尔滨
  • 出版信息:
    2013 年 (94 - 94)
  • 摘要:

    Many previous studies have shown that maternal ethanol exposure can induce physical and mental disorders in offspring, but the effect of paternal ethanol exposure on offspring is not clear.The changes in methylation in imprinted genes may be related to the teratogenic effects of ethanol, which have featured in many recent studies.In the present work, gavage doses of ethanol (0 g/kg, 1.1 g/kg, 3.3 g/kg) were administered to male Kunming (KM) mice.Then a behavioral study was performed on their F1 generation.

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