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Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin 期刊论文

编号：

d340ae5c-0725-4454-8340-23a3ae5fe8c9
作者：

Jiang, Wei(蒋维)^[1,2,3]Zhou, Xiaoyan(周晓燕)^[4,5,6]Li, Zengxia^[1];Liu, Kaiyu^[1];Wang, Weige^[4,5,6];Tan, Renke^[1];Cong, Xiaoji^[7];Shan, Jiaoyu^[8];Zhan, Yanxia^[9,10];Cui, Zhaomeng^[1];Jiang, Lizhi^[1];Li, Quanfu;Shen, Suqin^[11];Bai, Meirong^[2,3];Cheng, Yunfeng^[9,10];Li, Bin^[8];Tan, Minjia^[7];Ma, Dengke K.^[2,3];Liu, Jun O.^[12];Dang, Yongjun(党永军)^[1]
语种：

English
期刊：

BLOOD ISSN：0006-4971 2018 年 131 卷 12 期 (1325 - 1336) ; MAR 22
收录：
摘要：

B-cell lymphomas are heterogeneous blood disorders with limited therapeutic options, largely because of their propensity to relapse and become refractory to treatments. Carabin, a key suppressor of B-cell receptor signaling and proliferation, is inactivated in B-cell lymphoma by unknown mechanisms. Here, we identify prolyl 4-hydroxylase 2 (P4HA2) as a specific proline hydroxylase of Carabin. Carabin hydroxylation leads to its proteasomal degradation, thereby activating the Ras/extracellular signal-regulated kinase pathway and increasing B-cell lymphoma proliferation. P4HA2 is undetectable in normal B cells but upregulated in the diffuse large B-cell lymphoma (DLBCL), driving Carabin inactivation and lymphoma proliferation. Our results indicate that P4HA2 is a potential prognosis marker for DLBCL and a promising pharmacological target for developing treatment of molecularly stratified B-cell lymphomas.
推荐引用方式
GB/T 7714：

Jiang Wei,Zhou Xiaoyan,Li Zengxia, et al. Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin [J].BLOOD,2018,131(12):1325-1336.
APA：

Jiang Wei,Zhou Xiaoyan,Li Zengxia,Liu Kaiyu,&Dang Yongjun.(2018).Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin .BLOOD,131(12):1325-1336.
MLA：

Jiang Wei, et al. "Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin" .BLOOD 131,12(2018):1325-1336.

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