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Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells 期刊论文

编号：

d47e1d05-9ccb-4fff-88df-5c52e0466a2c
作者：

Wei, Yuanyan(魏湲颜)^[1]Jiang, Yizhou^[1];Zou, Fei^[1];Liu, Yingchao^[2];Wang, Shanshan^[1];Xu, Nuo^[1];Xu, Wenlong^[3];Cui, Chunhong^[1];Xing, Yang^[1];Liu, Ying(刘颖)^[1]Cao, Benjin^[1];Liu, Chanjuan^[1];Wu, Guoqiang^[1];Ao, Hong^[4];Zhang, Xiaobiao^[3];Jiang, Jianhai(江建海)^[1]
语种：

English
期刊：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ISSN：0027-8424 2013 年 110 卷 17 期 (6829 - 6834) ; APR 23
收录：
摘要：

The biological significance of a known normal and cancer stem cell marker CD133 remains elusive. We now demonstrate that the phosphorylation of tyrosine-828 residue in CD133 C-terminal cytoplasmic domain mediates direct interaction between CD133 and phosphoinositide 3-kinase (PI3K) 85 kDa regulatory subunit (p85), resulting in preferential activation of PI3K/protein kinase B (Akt) pathway in glioma stemcell (GSC) relative to matched nonstem cell. CD133 knockdown potently inhibits the activity of PI3K/Akt pathway with an accompanying reduction in the self-renewal and tumorigenicity of GSC. The inhibitory effects of CD133 knockdown could be completely rescued by expression of WT CD133, but not its p85-binding deficient Y828F mutant. Analysis of glioma samples reveals that CD133 Y828 phosphorylation level is correlated with histopathological grade and overlaps with Akt activation. Our results identify the CD133/PI3K/Akt signaling axis, exploring the fundamental role of CD133 in glioma stem cell behavior.
推荐引用方式
GB/T 7714：

Wei Yuanyan,Jiang Yizhou,Zou Fei, et al. Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells [J].PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2013,110(17):6829-6834.
APA：

Wei Yuanyan,Jiang Yizhou,Zou Fei,Liu Yingchao,&Jiang Jianhai.(2013).Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells .PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(17):6829-6834.
MLA：

Wei Yuanyan, et al. "Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells" .PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110,17(2013):6829-6834.

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