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New-onset diabetes after liver transplantation and its impact on complications and patient survival 期刊论文

编号：

d56fe576-f114-4260-9f28-0e7ec3f32e97
作者：

Lv, Chaoyang(吕朝阳)#^[1]Zhang, Yao(张尧)^[1]Chen, Xianying^[1,4];Huang, Xiaowu^[2];Xue, Mengjuan(薛孟娟)^[1]Sun, Qiman^[2];Wang, Ting^[2];Liang, Jing(梁璟)^[1]He, Shunmei(何顺梅)^[1]Gao, Jian^[3];Zhou, Jian^[2];Yu, Mingxiang(于明香)*^[1]Fan, Jia(樊嘉)^[2]Gao, Xin(高鑫)^[1]
语种：

English
期刊：

JOURNAL OF DIABETES ISSN：1753-0393 2015 年 7 卷 6 期 (881 - 890) ; NOV
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关键词：

fasting plasma glucose liver transplantation new-onset diabetes after transplant postoperative complications
摘要：

BackgroundThe aim of the present study was to investigate the incidence and risk factors of new-onset diabetes after transplantation (NODAT) in liver transplant recipients and the influence of NODAT on complications and long-term patient survival. MethodsWe examined 438 patients who underwent liver transplantation between April 2001 and December 2008 and were not diabetic before transplantation. ResultsThe mean (SD) follow-up duration was 2.461.62 years. The incidence of NODAT 3, 6, 9, 12, 36, and 60 months after transplantation was 44.24%, 25.59%, 23.08%, 25.17%, 17.86%, and 18.18%, respectively. Multifactor analysis indicated that preoperative fasting plasma glucose (FPG) levels and donor liver steatosis were independent risk factors for NODAT, whereas administration of an interleukin-2 receptor (IL-2R) antagonist reduced the risk of NODAT. Compared with the no NODAT group (N-NODAT), the NODAT group had a higher rate of sepsis and chronic renal insufficiency. Mean survival was significantly longer in the N-NODAT than NODAT group. Cox regression analysis showed that pre- and/or postoperative FPG levels, tumor recurrence or metastasis, and renal insufficiency after liver transplantation were independent risk factors of mortality. Pulmonary infection or multisystem failure were specific causes of death in the NODAT group, whereas patients in both groups died primarily from tumor relapse or metastasis. ConclusionsPreoperative FPG levels and donor liver steatosis were independent risk factors for NODAT, whereas administration of an IL-2R antagonist reduced the risk of NODAT. Patients with NODAT had reduced survival and an increased incidence of sepsis and chronic renal insufficiency. Significant causes of death in the NODAT group were pulmonary infection and multisystem failure.
推荐引用方式
GB/T 7714：

Lv Chaoyang,Zhang Yao,Chen Xianying, et al. New-onset diabetes after liver transplantation and its impact on complications and patient survival [J].JOURNAL OF DIABETES,2015,7(6):881-890.
APA：

Lv Chaoyang,Zhang Yao,Chen Xianying,Huang Xiaowu,&Gao Xin.(2015).New-onset diabetes after liver transplantation and its impact on complications and patient survival .JOURNAL OF DIABETES,7(6):881-890.
MLA：

Lv Chaoyang, et al. "New-onset diabetes after liver transplantation and its impact on complications and patient survival" .JOURNAL OF DIABETES 7,6(2015):881-890.

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