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Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma 期刊论文

编号：

d5818982-d129-4b91-8de9-70d932308f2f
作者：

Ge, Tianxiang^[1,2];Shen, Qiujin^[2];Wang, Ning^[2];Zhang, Yurong^[2];Ge, Zhouhong^[2];Chu, Wei^[2];Lv, Xiufang^[3];Zhao, Fengbo^[3];Zhao, Weifeng^[4];Fan, Jia(樊嘉)^[5]Qin, Wenxin^[2];
语种：

English
期刊：

MEDICAL ONCOLOGY ISSN：1357-0560 2015 年 32 卷 3 期 ; MAR
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关键词：

Hepatocellular carcinoma Alpha-fetoprotein Dickkopf-1 Osteopontin Diagnosis
摘要：

The timely diagnosis and effective treatment are essential for improving the survival and prognosis of hepatocellular carcinoma (HCC) patients. Alpha-fetoprotein (AFP) is the most widely used biomarker for diagnosis of HCC, but the low sensitivity and specificity limits its clinical application. In this study, we evaluated the diagnostic capability of the combination of AFP with two novel potential biomarkers, dickkopf-1 (DKK1) and osteopontin (OPN), for HCC in 390 participants including 89 patients with HCC, 36 patients with liver cirrhosis, 65 patients with chronic hepatitis B, and 200 health controls. We found the combination of all three markers as a panel showed a better diagnostic performance than that of AFP alone, with increased AUC [0.948 (95 % CI 0.921-0.968) vs. 0.831 (95 % CI 0.790-0.867)] and sensitivity (88.76 vs. 71.91 %). Moreover, this combination showed a great improvement in diagnosing early-stage HCC patients. In conclusion, the combined use of AFP, DKK1, and OPN as a biomarker panel could enhance the diagnostic ability for HCC.
推荐引用方式
GB/T 7714：

Ge Tianxiang,Shen Qiujin,Wang Ning, et al. Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma [J].MEDICAL ONCOLOGY,2015,32(3).
APA：

Ge Tianxiang,Shen Qiujin,Wang Ning,Zhang Yurong,&Qin Wenxin.(2015).Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma .MEDICAL ONCOLOGY,32(3).
MLA：

Ge Tianxiang, et al. "Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma" .MEDICAL ONCOLOGY 32,3(2015).

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