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Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors 期刊论文

编号：

d582b936-db12-4b05-9986-6d024d70cb08
作者：

Shi, DaKuo^[2];Zhang, Wei(张伟)^[1]Ding, Ning^[1];Li, Ming^[2];Li, YingXia(李英霞)*^[1]
语种：

English
期刊：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ISSN：0223-5234 2012 年 47 卷 (424 - 431) ; JAN
收录：
关键词：

Diphyllin Topo II inhibitors Synthesis Anticancer Structure-activity relationship
摘要：

Recently, a novel glycosylated diphyllin derivative 11 which exhibiting potent anticancer activity by targeting topoisomerase II alpha was reported by our group. In order to provide more molecules for structure-activity relationship (SAR) studies, 12 new glycosylated diphyllin analogs have been designed, synthesized, and evaluated for their biological activities. The SAR analysis revealed that (i) the sugar moiety on the diphyllin is essential for the anticancer activity; (ii) equatorial C4 '-OH on the sugar is superior to the axial one, and (iii) a proper cyclic lipophilic group at the C4' and C6' of sugar might enhance the anticancer activity. (C) 2011 Elsevier Masson SAS. All rights reserved.
推荐引用方式
GB/T 7714：

Shi Da-Kuo,Zhang Wei,Ding Ning, et al. Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors [J].EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2012,47:424-431.
APA：

Shi Da-Kuo,Zhang Wei,Ding Ning,Li Ming,&Li Ying-Xia.(2012).Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors .EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,47:424-431.
MLA：

Shi Da-Kuo, et al. "Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors" .EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 47(2012):424-431.

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