BackgroundProgrammed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it's essential to elicit the PD-1 related immune process in different types of cancer.MethodsThe Cancer Genome Atlas was used to collect the RNA-seq data of 33 cancer types. The microenvironment cell populations-counter was used to analyze the immune cell infiltrates. KEGG and GO analysis were performed to investigate PD-1 associated biological process. Kaplan-Meier survival curves and Cox's proportional hazards model were performed for prognostic value analysis.ResultsWe demonstrated that PD-1 expression varied in different cancer types. The uveal melanoma had a low PD-1 expression and poor infiltrated with immune cells. But it showed the strong correlation of PD-1 with the most types of immune cells. The PD-1 demonstrated a robust relationship with other immunomodulators and showed its involvement in critical functions correlated with anti-tumor immune pathways. Survival analysis indicated the PD-1 expression suggested different prognosis in different cancer types.ConclusionsOur investigations promote a better understanding of the PD-1 blockade and provide PD-1 related personized combined immunotherapy for different types of cancer patients.
[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Thorac Surg, 1277 Jiefang Rd, Wuhan 430022, Hubei, Peoples R China;
[2]Genius Med Consortium TGMC, Shanghai, Peoples R China;
[3]Fudan Univ, Shanghai Canc Ctr, Dept Med Oncol, 270 Dong An Rd, Shanghai 200032, Peoples R China;
[4]Fudan Univ, Shanghai Med Coll, Dept Oncol, 130 Dong An Rd, Shanghai 200032, Peoples R China;
[5]Soochow Univ, Dept Hematol, Affiliated Hosp 1, Suzhou 215006, Peoples R China;
[6]Zhengzhou Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Zhengzhou, Henan, Peoples R China;
[7]Fudan Univ, Zhongshan Hosp, Dept Dermatol, Shanghai 200032, Peoples R China;
[8]Fudan Univ, Sch Life Sci, 2005 Songhu Rd, Shanghai, Peoples R China
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