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Ca2+-Activated K+ Channels Reduce Network Excitability, Improving Adaptability and Energetics for Transmitting and Perceiving Sensory Information 期刊论文

编号：

d6696f9c-b7e2-4af7-a3dc-a443b07a29d6
作者：

Li, Xiaofeng^[1,2] Abou Tayoun, Ahmad^[3] Song, Zhuoyi^[2,4,5] Dau, An^[2] Rien, Diana^[1,2] Jaciuch, David^[2] Dongre, Sidhartha^[2] Blanchard, Florence^[2] Nikolaev, Anton^[2] Zheng, Lei^[2] Bollepalli, Murali K.^[4,5,6] Chu, Brian^[4,5,6] Hardie, Roger C.^[4,5,6] Dolph, Patrick J.^[3] Juusola, Mikko^[1,2]
语种：

英文
期刊：

JOURNAL OF NEUROSCIENCE ISSN：0270-6474 2019 年 39 卷 36 期 (7132 - 7154) ; SEP 4
收录：
关键词：

BK and SK channels homeostatic compensation network adaptation neural energy consumption synaptic feedback visual information sampling and processing
摘要：

Ca2+-activated K+ channels (BK and SK) are ubiquitous in synaptic circuits, but their role in network adaptation and sensory perception remains largely unknown. Using electrophysiological and behavioral assays and biophysical modeling, we discover how visual information transfer in mutants lacking the BK channel (dSlo(-)), SK channel (dSK(-)), or both (dSK(-);; dSlo(-)) is shaped in the female fruit fly (Drosophila melanogaster) R1-R6 photoreceptor-LMC circuits (R-LMC-R system) through synaptic feedforward-feedback interactions and reduced R1-R6 Shaker and Shab K+ conductances. This homeostatic compensation is specific for each mutant, leading to distinctive adaptive dynamics. We show how these dynamics inescapably increase the energy cost of information and promote the mutants' distorted motion perception, determining the true price and limits of chronic homeostatic compensation in an in vivo genetic animal model. These results reveal why Ca2+ -activated K+ channels reduce network excitability (energetics), improving neural adaptability for transmitting and perceiving sensory information.
推荐引用方式
GB/T 7714：

Li Xiaofeng,Abou Tayoun Ahmad,Song Zhuoyi, et al. Ca2+-Activated K+ Channels Reduce Network Excitability, Improving Adaptability and Energetics for Transmitting and Perceiving Sensory Information [J].JOURNAL OF NEUROSCIENCE,2019,39(36):7132-7154.
APA：

Li Xiaofeng,Abou Tayoun Ahmad,Song Zhuoyi,Dau An,&Juusola Mikko.(2019).Ca2+-Activated K+ Channels Reduce Network Excitability, Improving Adaptability and Energetics for Transmitting and Perceiving Sensory Information .JOURNAL OF NEUROSCIENCE,39(36):7132-7154.
MLA：

Li Xiaofeng, et al. "Ca2+-Activated K+ Channels Reduce Network Excitability, Improving Adaptability and Energetics for Transmitting and Perceiving Sensory Information" .JOURNAL OF NEUROSCIENCE 39,36(2019):7132-7154.

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