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Radiosynthesis of C-11-Levetiracetam: A Potential Marker for PET Imaging of SV2A Expression 期刊论文

编号：

d6f2f983-3942-4422-ada5-f79271a547e9
作者：

Cai, Hancheng^[1,2,5,6];Mangner, Thomas J.^[1,2,3];Muzik, Otto^[1,2,3];Wang, MingWei(王明伟)^[7,8]Chugani, Diane C.^[1,2,3];Chugani, Harry T.^[1,2,3,4];
语种：

English
期刊：

ACS MEDICINAL CHEMISTRY LETTERS ISSN：1948-5875 2014 年 5 卷 10 期 (1152 - 1155) ; OCT
收录：
关键词：

Levetiracetam synaptic vesicle protein 2A positron emission tomography carbon-11
摘要：

The multistep preparation of C-11-levetiracetam ((CLEV)-C-11) was carried out by a one-pot radiosynthesis with 8.3 +/- 1.6% (n = 8) radiochemical yield in 50 +/- 5.0 min. Briefly, the propionaldehyde was converted to propan-l-imine in situ as labeling precursor by incubation with ammonia. Without further separation, the imine was reacted with C-11-HCN to form C-11-aminonitrile. This crude was then reacted with 4-chlorobutyryl chloride and followed by hydrolysis to yield C-11-LEV after purification by chiral high-performance liquid chromatography (HPLC). Both the radiochemical and enantiomeric purities of C-11-LEV were >98%.
推荐引用方式
GB/T 7714：

Cai Hancheng,Mangner Thomas J.,Muzik Otto, et al. Radiosynthesis of C-11-Levetiracetam: A Potential Marker for PET Imaging of SV2A Expression [J].ACS MEDICINAL CHEMISTRY LETTERS,2014,5(10):1152-1155.
APA：

Cai Hancheng,Mangner Thomas J.,Muzik Otto,Wang Ming-Wei,&Chugani Harry T..(2014).Radiosynthesis of C-11-Levetiracetam: A Potential Marker for PET Imaging of SV2A Expression .ACS MEDICINAL CHEMISTRY LETTERS,5(10):1152-1155.
MLA：

Cai Hancheng, et al. "Radiosynthesis of C-11-Levetiracetam: A Potential Marker for PET Imaging of SV2A Expression" .ACS MEDICINAL CHEMISTRY LETTERS 5,10(2014):1152-1155.

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