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Suppression of Autophagy Enhanced Growth Inhibition and Apoptosis of Interferon-beta in Human Glioma Cells 期刊论文

编号：

d82002eb-f068-4dd7-9413-9440f4024c1d
作者：

Li, Yubin(李玉彬)#^[1,2]Zhu, Haiyan(朱海燕)^[1]Zeng, Xian(曾贤)^[1]Fan, Jiajun(范佳君)^[1]Qian, Xiaolu^[3];Wang, Shaofei^[1];Wang, Ziyu(王子玉)^[1]Sun, Yun^[1];Wang, Xiaodan^[4];Wang, Weiwu^[2];Ju, Dianwen(鞠佃文)*^[1,5,6]
语种：

English
期刊：

MOLECULAR NEUROBIOLOGY ISSN：0893-7648 2013 年 47 卷 3 期 (1000 - 1010) ; JUN
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关键词：

Autophagy IFN-beta Glioma cells Growth inhibition Apoptosis
摘要：

Interferon-beta (IFN-beta) is a cytokine with anti-viral, anti-proliferative, and immunomodulatory effects. In this study, we investigated the effects of IFN-beta on the induction of autophagy and the relationships among autophagy, growth inhibition, and apoptosis induced by IFN-beta in human glioma cells. We found that IFN-beta induced autophagosome formation and conversion of microtubule associated protein 1 light chain 3 (LC3) protein, whereas it inhibited cell growth through caspase-dependent cell apoptosis. The Akt/mTOR signaling pathway was involved in autophagy induced by IFN-beta. A dose- and time-dependent increase of p-ERK 1/2 expression was also observed in human glioma cells treated with IFN-beta. Autophagy induced by IFN-beta was suppressed when p-ERK1/2 was impaired by treatment with U0126. We also demonstrated that suppression of autophagy significantly enhanced growth inhibition and cell apoptosis induced by IFN-beta, whereas inhibition of caspase-dependent cell apoptosis impaired autophagy induced by IFN-beta. Collectively, these findings indicated that autophagy induced by IFN-beta was associated with the Akt/mTOR and ERK 1/2 signaling pathways, and inhibition of autophagy could enhance the growth inhibitory effects of IFN-beta and increase apoptosis in human glioma cells. Together, these findings support the possibility that autophagy inhibitors may improve IFN-beta therapy for gliomas.
推荐引用方式
GB/T 7714：

Li Yubin,Zhu Haiyan,Zeng Xian, et al. Suppression of Autophagy Enhanced Growth Inhibition and Apoptosis of Interferon-beta in Human Glioma Cells [J].MOLECULAR NEUROBIOLOGY,2013,47(3):1000-1010.
APA：

Li Yubin,Zhu Haiyan,Zeng Xian,Fan Jiajun,&Ju Dianwen.(2013).Suppression of Autophagy Enhanced Growth Inhibition and Apoptosis of Interferon-beta in Human Glioma Cells .MOLECULAR NEUROBIOLOGY,47(3):1000-1010.
MLA：

Li Yubin, et al. "Suppression of Autophagy Enhanced Growth Inhibition and Apoptosis of Interferon-beta in Human Glioma Cells" .MOLECULAR NEUROBIOLOGY 47,3(2013):1000-1010.

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