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Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Development Egress Blockage 期刊论文

编号：

d9a9937b-ba47-4010-a49c-a5896b2160fa
作者：

Geng, Shuang^[1,6];Zhong, Yiwei^[1];Zhou, Xiaoyu^[1];Zhao, Gan^[1];Xie, Xiaoping^[2];Pei, Yechun^[2];Liu, Hu^[2];Zhang, Huiyuan^[2];Shi, Yan^[3,4,5];Wang, Bin(王宾)^[1]
语种：

English
期刊：

FRONTIERS IN IMMUNOLOGY ISSN：1664-3224 2017 年 8 卷 ; JUN 7
收录：
关键词：

inducible regulatory T cell antigen specific suppression hilar lymph node airway inflammation egress S1p1
摘要：

Regulatory T cells (Tregs) restrict overexuberant lymphocyte activation. While close proximity between Tregs and their suppression targets is important for optimal inhibition, and literature indicates that draining lymph nodes (LNs) may serve as a prime location for the suppression, signaling details orchestrating this event are not fully characterized. Using a protocol to enable peripheral generation of inducible antigen-specific Tregs (asTregs) to control allergen-induced asthma, we have identified an antigen-specific mechanism that locks asTregs within hilar LNs which in turn suppresses airway inflammation. The suppressive asTregs, upon antigen stimulation in the LN, downregulate sphingosine-1-phosphate receptor 1 egress receptor expression. These asTregs in turn mediate the downregulation of the same receptor on incoming effector T cells. Therefore, asTregs and effector T cells are locked in these draining LNs for prolonged interactions. Disruption of individual steps of this retention sequence abolishes the inflammation controlled by asTregs. Collectively, this study identifies a new requirement of spatial congregation with their suppression targets essential for asTreg functions and suggests therapeutic programs via Treg traffic control.
推荐引用方式
GB/T 7714：

Geng Shuang,Zhong Yiwei,Zhou Xiaoyu, et al. Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Development Egress Blockage [J].FRONTIERS IN IMMUNOLOGY,2017,8.
APA：

Geng Shuang,Zhong Yiwei,Zhou Xiaoyu,Zhao Gan,&Wang Bin.(2017).Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Development Egress Blockage .FRONTIERS IN IMMUNOLOGY,8.
MLA：

Geng Shuang, et al. "Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Development Egress Blockage" .FRONTIERS IN IMMUNOLOGY 8(2017).

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