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Identification and characterization of the promoter of human ATF5 gene 期刊论文

编号：

db70d136-d481-40e6-b9f7-2c32ecc82df3
作者：

Wei, Yuanyan Ge, Yuqing Zhou, Fengbiao Chen, Hong Cui, Chunhong Liu, Dan Yang, Zhiyuan Wu, Guoqiang Gu, Jianxin Jiang, Jianhai^[1]
语种：

English
期刊：

JOURNAL OF BIOCHEMISTRY ISSN：0021-924X 2010 年 148 卷 2 期 (171 - 178) ; AUG
收录：
关键词：

ATF5 EBF1 promoter transcription factors transcriptional regulation
摘要：

ATF5, a member of ATF/CREB family of b-ZIP transcription factors, is highly expressed in a wide variety of neoplasms and regulates cell differentiation, cell survival and apoptosis. However, the mechanism of human ATF5 transcriptional regulation has not been clarified. Here, we identified the transcription start site of the ATF5 gene, cloned its 5'-flanking region and identified the region -105 to +3 relative to the transcription start site as that having promoter activity. This region contained potential binding sites for several transcription factors, including EBF1, Sp1 and E2F1. EBF1 transcription factor binds to the ATF5 promoter and regulates the ATF5 transcription in an EBF-binding site independent manner. Thus, our studies not only provided molecular basis of ATF5 transcriptional regulation, but also identified ATF5 as a target gene of EBF1 transcription factor.
推荐引用方式
GB/T 7714：

Wei Yuanyan,Ge Yuqing,Zhou Fengbiao, et al. Identification and characterization of the promoter of human ATF5 gene [J].JOURNAL OF BIOCHEMISTRY,2010,148(2):171-178.
APA：

Wei Yuanyan,Ge Yuqing,Zhou Fengbiao,Chen Hong,&Jiang Jianhai.(2010).Identification and characterization of the promoter of human ATF5 gene .JOURNAL OF BIOCHEMISTRY,148(2):171-178.
MLA：

Wei Yuanyan, et al. "Identification and characterization of the promoter of human ATF5 gene" .JOURNAL OF BIOCHEMISTRY 148,2(2010):171-178.

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