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Olmesartan Attenuates Cardiac Hypertrophy and Improves Cardiac Diastolic Function in Spontaneously Hypertensive Rats Through Inhibition of Calcineurin Pathway 期刊论文

编号：

de38796b-3b46-4ed4-b9c8-3d8c55743ef2
作者：

Fu, Mingqiang(付明强)#^[1]Zhou, Jingmin(周京敏)^[1]Xu, Jianfeng^[1];Zhu, Hongmin(朱虹岷)^[1]Liao, Jianquan^[1];Cui, Xiaotong(崔晓通)^[1]Sun, Aijun(孙爱军)^[1]Fu, Michael^[2];Zou, Yunzeng(邹云增)^[1,3]Hu, Kai(胡凯)^[1]Ge, Junbo(葛均波)*^[1,3]
语种：

English
期刊：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY ISSN：0160-2446 2014 年 63 卷 3 期 (218 - 226) ; MAR
收录：
关键词：

diastolic function spontaneously hypertensive rats calcineurin pathway olmesartan
摘要：

Objective: To test whether olmesartan ameliorates cardiac diastolic dysfunction in spontaneously hypertensive rats (SHRs) through calcineurin pathway. Methods: Twenty-four male SHRs of 6 months were divided into saline- (n = 12) and olmesartan-treated (n = 12) groups. Age-matched WKY (n = 12) rats served as controls. Saline (10 mL center dot kg center dot d) or the same volume of olmesartan liquor (2.5 mg center dot kg center dot d) was administered by gavage for 3 months. Heart rate, systolic blood pressure, cardiac structure, and function and histological studies were determined. Expression of calcineurin and downstream NFAT3 were also detected. Results: Compared with age-matched Wistar Kyoto rats, SHRs of 6 months exhibited evident cardiac hypertrophy and diastolic dysfunction as demonstrated by elevated systolic blood pressure and E/E ', decreased E/A and E '/A ', while F, left ventricular ejection fraction and fractional shortening remained unimpaired. Treatment with olmesartan significantly decreased systolic blood pressure and ventricular hypertrophy, attenuated fibrosis, and improved diastolic function (all P < 0.05). Meanwhile, both calcineurin and NFAT3 expressions were downregulated in olmesartan group compared with the other 2 groups (both P < 0.05). Conclusions: These data suggest the beneficial effect of olmesartan on cardiac structure and diastolic dysfunction, and it may be mediated through calcineurin pathway. This indicates a new therapeutic target for diastolic dysfunction.
推荐引用方式
GB/T 7714：

Fu Mingqiang,Zhou Jingmin,Xu Jianfeng, et al. Olmesartan Attenuates Cardiac Hypertrophy and Improves Cardiac Diastolic Function in Spontaneously Hypertensive Rats Through Inhibition of Calcineurin Pathway [J].JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,2014,63(3):218-226.
APA：

Fu Mingqiang,Zhou Jingmin,Xu Jianfeng,Zhu Hongmin,&Ge Junbo.(2014).Olmesartan Attenuates Cardiac Hypertrophy and Improves Cardiac Diastolic Function in Spontaneously Hypertensive Rats Through Inhibition of Calcineurin Pathway .JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,63(3):218-226.
MLA：

Fu Mingqiang, et al. "Olmesartan Attenuates Cardiac Hypertrophy and Improves Cardiac Diastolic Function in Spontaneously Hypertensive Rats Through Inhibition of Calcineurin Pathway" .JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 63,3(2014):218-226.

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