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PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma 期刊论文

编号：

e01bcc0f-8352-44fb-87e9-22c53f0013db
作者：

Wang, Yiwei(王一惟)#^[1]Wang, Hang(王杭)^[1]Zhao, Qi^[1];Xia, Yu^[1];Hu, Xiaoyi(胡骁轶)^[1]Guo, Jianming(郭剑明)*^[1]
语种：

English
期刊：

MEDICAL ONCOLOGY ISSN：1357-0560 2015 年 32 卷 8 期 ; AUG
收录：
关键词：

Programmed death ligand 1 Renal cell carcinoma Metastasis SREBP-1c
摘要：

The incidence of kidney cancer has been increasing globally during the past two decades. Renal cell carcinoma (RCC) is the most aggressive subtype of kidney cancer, which usually deteriorates with epithelial-mesenchymal transition (EMT) that facilitates the migration and invasion of cancer cells. Till now, the underlying mechanism remains unclear. In this study, we demonstrated that programmed death ligand 1 (PD-L1/B7-H1/CD274) could induce EMT and enhance RCC cell cancer stemness through up-regulation of SREBP-1c. Furthermore, we found that PD-L1 is up-regulated in human RCC metastases. These results, taken together, provide evidence for a novel mechanism of PD-L1 in RCC progression, suggesting that there is a close relationship between EMT and immune escape signaling pathways in RCC.
推荐引用方式
GB/T 7714：

Wang Yiwei,Wang Hang,Zhao Qi, et al. PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma [J].MEDICAL ONCOLOGY,2015,32(8).
APA：

Wang Yiwei,Wang Hang,Zhao Qi,Xia Yu,&Guo Jianming.(2015).PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma .MEDICAL ONCOLOGY,32(8).
MLA：

Wang Yiwei, et al. "PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma" .MEDICAL ONCOLOGY 32,8(2015).

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