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Modifying Effect of COMT Gene Polymorphism and a Predictive Role for Proteomics Analysis in Children's Intelligence in Endemic Fluorosis Area in Tianjin, China 期刊论文

编号：

e1862fc0-b96a-42f2-befd-b31e3f4ee468
作者：

Zhang, Shun^[1,2];Zhang, Xiaofei^[1,2];Liu, Hongliang^[3];Qu, Weidong(屈卫东)^[4,5]Guan, Zhizhong^[6];Zeng, Qiang^[3];Jiang, Chunyang^[1,2];Gao, Hui^[1,2];Zhang, Cheng^[1,2];Lei, Rongrong^[1,2];Xia, Tao^[1,2];Wang, Zhenglun^[1,2];Yang, Lu^[1,2];Chen, Yihu^[1,2];Wu, Xue^[1,2];Cui, Yushan^[3];Yu, Linyu^[3];Wang, Aiguo^[1,2];
语种：

English
期刊：

TOXICOLOGICAL SCIENCES ISSN：1096-6080 2015 年 144 卷 2 期 (238 - 245) ; APR
收录：
关键词：

children's IQ COMT polymorphism fluoride plasma proteomic
摘要：

Cumulative fluoride exposure has adverse influences on children's intelligence quotient (IQ). In addition, catechol-O-methyltransferase (COMT) gene Val158Met polymorphism (rs4680) is associated with cognitive performance. This study aimed to evaluate the associations of COMT polymorphism and alterations of protein profiles with children's intelligence in endemic fluorosis area. We recruited 180 schoolchildren (10-12 years old) from high fluoride exposure (1.40 mg/l) and control areas (0.63 mg/l) in Tianjin City, China. The children's IQ, fluoride contents in drinking water (W-F), serum (S-F), and urine (U-F); serum thyroid hormone levels, COMT Val158Met polymorphism, and plasma proteomic profiling were determined. Significant high levels of W-F, S-F, U-F, along with poor IQ scores were observed in the high fluoride exposure group compared with those in control (all P < 0.05). S-F and U-F were inversely related with IQ (r(s) = -0.47, P < 0.01; r(s) = -0.45, P = 0.002). Importantly, higher fluoride exposure was associated with steeper cognitive decline among children with the reference allele Val compared with those homozygous or heterozygous for the variant allele Met (95% CI, -16.80 to 2.55; P interaction < 0.01). Additionally, 5 up-regulated protein spots related to cell immunity and metabolism were detected in children with high fluoride exposure compared with the control. In conclusion, fluoride exposure was adversely associated with children's intelligence, whereas the COMT polymorphism may increase the susceptibility to the deficits in IQ due to fluoride exposure. Moreover, the proteomic analysis can provide certain basis for identifying the early biological markers of fluorosis among children.
推荐引用方式
GB/T 7714：

Zhang Shun,Zhang Xiaofei,Liu Hongliang, et al. Modifying Effect of COMT Gene Polymorphism and a Predictive Role for Proteomics Analysis in Children's Intelligence in Endemic Fluorosis Area in Tianjin, China [J].TOXICOLOGICAL SCIENCES,2015,144(2):238-245.
APA：

Zhang Shun,Zhang Xiaofei,Liu Hongliang,Qu Weidong,&Wang Aiguo.(2015).Modifying Effect of COMT Gene Polymorphism and a Predictive Role for Proteomics Analysis in Children's Intelligence in Endemic Fluorosis Area in Tianjin, China .TOXICOLOGICAL SCIENCES,144(2):238-245.
MLA：

Zhang Shun, et al. "Modifying Effect of COMT Gene Polymorphism and a Predictive Role for Proteomics Analysis in Children's Intelligence in Endemic Fluorosis Area in Tianjin, China" .TOXICOLOGICAL SCIENCES 144,2(2015):238-245.

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