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Neonatal CX26 removal impairs neocortical development and leads to elevated anxiety 期刊论文

编号：

e2bcb37a-72c8-46bc-a1e2-694adf83c34c
作者：

Su, Xin^[1];Chen, JingJing^[1];Liu, LinYun(刘琳云)^[1]Huang, Qian^[1];Zhang, LiZhao^[1];Li, XiaoYang^[1];He, XiangNan^[2,3];Lu, Wenlian^[2,3];Sun, Shan^[4];Li, Huawei(李华伟)^[4]Yu, YongChun(禹永春)*^[1,5]
语种：

English
期刊：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ISSN：0027-8424 2017 年 114 卷 12 期 (3228 - 3233) ; MAR 21
收录：
关键词：

CX26 development anxiety neocortex
摘要：

Electrical coupling between excitatory neurons in the neocortex is developmentally regulated. It is initially prominent but eliminated at later developmental stages when chemical synapses emerge. However, it remains largely unclear whether early electrical coupling networks broadly contribute to neocortical circuit formation and animal behavior. Here, we report that neonatal electrical coupling between neocortical excitatory neurons is critical for proper neuronal development, synapse formation, and animal behavior. Conditional deletion of Connexin 26 (CX26) in the superficial layer excitatory neurons of the mouse neocortex around birth significantly reduces spontaneous firing activity and the frequency and size of spontaneous network oscillations at postnatal day 5-6. Moreover, CX26-conditional knockout (CX26-cKO) neurons tend to have simpler dendritic trees and lower spine density compared with wild-type neurons. Importantly, early, but not late, postnatal deletion of CX26, decreases the frequency of miniature excitatory postsynaptic currents (mEPSCs) in both young and adult mice, whereas miniature inhibitory postsynaptic currents (mIPSCs) were unaffected. Furthermore, CX26-cKO mice exhibit increased anxiety-related behavior. These results suggest that electrical coupling between excitatory neurons at early postnatal stages is a critical step for neocortical development and function.
推荐引用方式
GB/T 7714：

Su Xin,Chen Jing-Jing,Liu Lin-Yun, et al. Neonatal CX26 removal impairs neocortical development and leads to elevated anxiety [J].PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2017,114(12):3228-3233.
APA：

Su Xin,Chen Jing-Jing,Liu Lin-Yun,Huang Qian,&Yu Yong-Chun.(2017).Neonatal CX26 removal impairs neocortical development and leads to elevated anxiety .PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,114(12):3228-3233.
MLA：

Su Xin, et al. "Neonatal CX26 removal impairs neocortical development and leads to elevated anxiety" .PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114,12(2017):3228-3233.

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