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Predictive factors of para-aortic lymph nodes metastasis in cervical cancer patients: a retrospective analysis based on 723 para-aortic lymphadenectomy cases 期刊论文

编号：

e33c29af-3c21-4d79-b403-bb74ad9dd18e
作者：

Han, Xiaotian(韩啸天)#^[1,2]Wen, Hao(温灏)^[1,2]Ju, Xingzhu(居杏珠)^[1,2]Chen, Xiaojun(陈小军)^[1,2]Ke, Guihao(柯桂好)^[1,2]Zhou, Yuqi(周瑜琪)^[1,2]Li, Jin(李琎)^[1,2]Xia, Lingfang(夏玲芳)^[1,2]Tang, Jia^[1,2];Liang, Shanhui^[1,2];Wu, Xiaohua(吴小华)*^[1,2]
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2017 年 8 卷 31 期 (51840 - 51847) ; AUG 1
收录：
关键词：

cervical cancer para-aortic lymph node pelvic lymph node lymphadenectomy SCCA
摘要：

Para-aortic lymph node (PALN) dissection is optional and controversial in patients with stage IB1-IIA2 cervical cancer. This retrospective study investigated PALN involvement patterns and evaluated preoperative clinical factors. A total of 723 consecutive FIGO stage IB1-IIA2 cervical cancer patients were included in the study. All patients underwent radical hysterectomy/radical trachelectomy, pelvic lymph node dissection, and PALN dissection. PALN metastasis was found in 101 (14.0%) patients, and the positive PALN rates of stage IB1, IB2, IIA1, and IIA2 were 8.4%, 11.1%, 17.2% and 21.7%, respectively. A multivariate model suggested age > 46 years (OR: 1.67, 95% confidence interval (CI): 1.08-2.58), tumor size > 3.5 cm (OR: 1.79, 95% CI: 1.12-2.87), and FIGO stage IIA (vs. IB) (OR: 1.97, 95% CI: 1.25-3.11) all positively correlated with PALN metastasis. When squamous cervical cancer cases were categorically analyzed, a multivariate model indicated age > 46 years (OR: 1.67, 95% CI: 1.00-2.80), FIGO stage IIA (vs. IB) (OR: 1.76, 95% CI: 1.02-3.02), and squamous cell carcinoma antigen (SCCA) > 6.5 ng/ml (OR: 5.20, 95% CI: 3.07-8.81) all positively correlated with PALN metastasis. Age, tumor size, and FIGO stage correlated with PALN metastasis in cervical cancer, while age, FIGO stage, and SCCA level were predictive in squamous cell carcinoma.
推荐引用方式
GB/T 7714：

Han Xiaotian,Wen Hao,Ju Xingzhu, et al. Predictive factors of para-aortic lymph nodes metastasis in cervical cancer patients: a retrospective analysis based on 723 para-aortic lymphadenectomy cases [J].ONCOTARGET,2017,8(31):51840-51847.
APA：

Han Xiaotian,Wen Hao,Ju Xingzhu,Chen Xiaojun,&Wu Xiaohua.(2017).Predictive factors of para-aortic lymph nodes metastasis in cervical cancer patients: a retrospective analysis based on 723 para-aortic lymphadenectomy cases .ONCOTARGET,8(31):51840-51847.
MLA：

Han Xiaotian, et al. "Predictive factors of para-aortic lymph nodes metastasis in cervical cancer patients: a retrospective analysis based on 723 para-aortic lymphadenectomy cases" .ONCOTARGET 8,31(2017):51840-51847.

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