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Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5 期刊论文

编号：

e3427850-ce85-4af6-b8d9-8a9b427c1456
作者：

Hu, Ziying^[1,2];Chen, Minjie^[2,3];Zhou, Huifen^[2,4];Tharakan, Anui^[5];Wang, Xiaoke^[2,6];Qiu, Lianglin^[2,6];Liang, Shuai^[2];Qin, Xiaobo^[2];Zhang, Yuhao(张宇浩)^[7]Wang, Wanjun^[3];Xu, Yanyi(徐燕意)*^[3]Ying, Zhekang^[2,3];
语种：

English
期刊：

TOXICOLOGY ISSN：0300-483X 2017 年 390 卷 (100 - 108) ; SEP 1
收录：
关键词：

Ambient PM2.5 Tumor necrosis factor Lymphotoxin Obesity Inflammation
摘要：

Background: Exposure to ambient fine particulate matter (PM2.5) is associated with increased cardiometabolic morbidity and mortality. This is widely believed to be attributable to PM2.5 exposure-induced pulmonary and subsequent systemic inflammation. Tumor necrosis factor alpha (TNF alpha), lymphotoxin alpha (LT alpha), and lymphotoxin beta (LT beta) are three homologous pro-inflammatory cytokines, each with both unique and redundant activities in inflammation. Their role in PM2.5 exposure-induced inflammation and adverse cardiometabolic effects has to be determined. Methods and results: LT alpha/TNF alpha/LT beta triple-knockout (TNF/LT KO) and wildtype (WT) mice were exposed to concentrated ambient PM2.5 (CAP) for 5 months. Lung pathological analysis revealed that TNF/LT deficiency reduced CAP exposure-induced pulmonary inflammation. However, glucose homeostasis assessments showed that TNF/LT deficiency significantly aggravated CAP exposure-induced glucose intolerance and insulin resistance. Consistent with glucose homeostasis assessments, CAP exposure significantly increased the body weight and adiposity of TNF/LT KO but not WT mice. In contrast to its body weight effects, CAP exposure reduced food intake of WT but not TNF/LT KO mice. On the other hand, CAP exposure induced marked fat droplet accumulation in brown adipose tissues of WT mice and significantly decreased their uncoupling protein 1 (UCP1) expression, and these effects were markedly exacerbated in TNF/LT KO mice. Conclusion: The present study suggests that TNF/LT deficiency influences PM2.5 exposure-induced response of energy metabolism through alterations in both food intake and energy expenditure.
推荐引用方式
GB/T 7714：

Hu Ziying,Chen Minjie,Zhou Huifen, et al. Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5 [J].TOXICOLOGY,2017,390:100-108.
APA：

Hu Ziying,Chen Minjie,Zhou Huifen,Tharakan Anui,&Ying Zhekang.(2017).Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5 .TOXICOLOGY,390:100-108.
MLA：

Hu Ziying, et al. "Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5" .TOXICOLOGY 390(2017):100-108.

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