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Physical activity, body size, and estrogen metabolism in women 期刊论文

编号：

e67d85ef-2047-4a2e-b540-7cc518041a4b
作者：

Matthews, Charles E.[0]^[1] Fowke, Jay H.[1]^[2] Dai, Qi[2]^[3] Bradlow, H. Leon[3]^[4] Jin, Fan[4]^[5] Shu, Xiaoou[5]^[6] Gao, Yutang[6]^[7] Longcope, Christopher[7]^[8] Hébert, James R.[8]^[9] Zheng, Wei[9]^[6]
地址：

[1]National Cancer Institute, Division of Cancer Epidemiology and Genetics,Bethesda,United States
[2]VA Medical Center, Departments of Medicine and Surgery,,United States
[3]Vanderbilt University School of Medicine, Department of Medicine,Nashville,United States
[4]Hackensack University Medical Center,Hackensack,United States
[5]Medical Center of Fudan University, Shanghai Cancer Institute,Shanghai,China
[6]Vanderbilt Ingram Cancer Center, Department of Medicine,Nashville,United States
[7]Shanghai Jiaotong University, Department of Epidemiology,Shanghai,China
[8]University of Massachusetts Medical School, Departments of Obstetrics and Gynecology and Medicine,Worcester,United States
[9]University of South Carolina, Cancer Prevention and Control Program,Columbia,United States
语种：

英文
期刊：

Cancer Causes and Control ISSN：0957-5243 2004 年 15 卷 5 期 (473 - 481)
收录：
关键词：

body composition breast cancer estrogen metabolites exercise obesity
摘要：

Objectives: Physical activity has demonstrable effects on estrogen levels in pre- and postmenopausal women. Increased oxidation of estrone to 2-hydroxyestrone (2HE) relative to 16α-hydroxyestrone (16HE) has been hypothesized to reduce breast cancer risk, but little is known about the effect of physical activity and body size in relation to the ratio of 2HE and 16HE in women. We examined these relationships in cross-sectional analyses of 157 North American and Chinese women. Methods: Physical activity was assessed using validated questionnaires. Adiposity was assessed as body mass index (BMI, kg/m 2) and by anthropometric methods (% body fat). Estrone metabolites, 2HE and 16HE, were determined from urine via ELISA. Results: Regression analyses on the 2HE/16HE ratio revealed an interaction between leisure-time physical activities and adiposity in both North American and Chinese women (p ≤ 0.05). Women reporting low levels of leisure-time physical activity who had higher BMI levels had 2HE/16HE ratios that were lower than their lean counterparts. In contrast, women with higher BMI levels that were physically active maintained higher 2HE/16HE ratios. Conclusion: These findings suggest that physical activity participation has the potential to modify the adverse effect of increased adiposity on estrogen metabolism in North American and Chinese women.
推荐引用方式
GB/T 7714：

Matthews Charles E./7201785720[0],Fowke Jay H./6603068772[1],Dai Qi/56992138400[2], et al. Physical activity, body size, and estrogen metabolism in women [J].Cancer Causes and Control,2004,15(5):473-481.
APA：

Matthews Charles E./7201785720[0],Fowke Jay H./6603068772[1],Dai Qi/56992138400[2],Bradlow H. Leon/7103247488[3],&Zheng Wei/35381589100[9].(2004).Physical activity, body size, and estrogen metabolism in women .Cancer Causes and Control,15(5):473-481.
MLA：

Matthews Charles E./7201785720[0], et al. "Physical activity, body size, and estrogen metabolism in women" .Cancer Causes and Control 15,5(2004):473-481.

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