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FAK signaling pathway 期刊论文

编号：

e74a08bc-f017-478a-a66a-6ebc722bfa6e
作者：

Liu, Fei(刘霏)#^[1,2,4]Tong, Duo^[3,4];Li, Haoran(李浩然)^[1,2,4]Liu, Mingming^[1,2,4];Li, Jiajia^[1,2,4];Wang, Ziliang^[1,2,3,4];Cheng, Xi(程玺)*^[1,2,4]
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2016 年 7 卷 8 期 (8896 - 8907) ; FEB 23
收录：
关键词：

cervical cancer Bufalin integrin alpha 2/beta 5 FAK paclitaxel
摘要：

While Bufalin restrains primary tumorigenesis, the role of Bufalin in cervical cancer remains unclear. Here, we show that Bufalin can inhibit cervical cancer cell proliferation, block cell cycle in G2/M phase, induce cellular apoptosis and reduce cell metastasis through stimulation of p21(waf/cip1), p27(cip/kip), Bax and E-cadherin, and suppression of cyclin A, cyclin B1, CDK2, Bcl-2, Bcl-xl, MMP9 and SNAIL1. Further study suggests that Bufalin has no apparent damage to human normal cervical cells at the low concentration (<20nM), but increases the chemotherapeutic efficacy of paclitaxel. Mechanistic study reveals that Bufalin suppresses the integrin alpha 2/FAK/AKT1/GSK3 beta signaling. Finally, in vivo studies show that Bufalin blocks the Siha-induced xenograft tumor growth without detectable toxicity in the animals at the therapeutic doses, and the combination treatment of Bufalin and paclitaxel more efficiently inhibits xenograft tumor growth. Thus, Bufalin may be developed as a potential therapeutic agent to treat cervical cancer.
推荐引用方式
GB/T 7714：

Liu Fei,Tong Duo,Li Haoran, et al. Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin alpha 2/beta 5/FAK signaling pathway [J].ONCOTARGET,2016,7(8):8896-8907.
APA：

Liu Fei,Tong Duo,Li Haoran,Liu Mingming,&Cheng Xi.(2016).Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin alpha 2/beta 5/FAK signaling pathway .ONCOTARGET,7(8):8896-8907.
MLA：

Liu Fei, et al. "Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin alpha 2/beta 5/FAK signaling pathway" .ONCOTARGET 7,8(2016):8896-8907.

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