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Possibilities and potential roles of estrogen in the pathogenesis of proliferation hemangiomas formation 期刊论文

编号：

e7b827e5-21de-4c23-9292-5c23cfd3ffee
作者：

Sun, ZhiYong^[1] Yang, Li^[2] Yi, ChengGang^[2] Zhao, Huan^[3] Han, DaLi^[4] Yang, Tao^[5] Wang, Lu^[2] Nie, ChunLei^[6] Zhang, GuoYou^[1] Yin, GuoQian^[1] Wang, Gang^[1] Teng, XiaoPin^[1] Fei, DongMei^[7,8,9,10] Wang, Jin^[10] Zhou, WenKai^[11] Li, Yang^[2] Liu, Bin^[2] Liu, Yin^[12] Zhang, ManJing^[12] Wu, ShangMin^[12] Zhang, Xi^[2] Pan, Hua^[2] Xiao, Bo^[2] Zhao, KeFeng^[2] Liu, Dan^[2] Guo, ShuZhong^[2]
语种：

English
期刊：

MEDICAL HYPOTHESES ISSN：0306-9877 2008 年 71 卷 2 期 (286 - 292) ; AUG
收录：
摘要：

Hemangiomas, often categorized as angiogenic diseases, are the most common tumors of infancy, the life span of which is generally divided into proliferating phase, involuting phase, and involuted phase. Despite their high prevalence, the mechanism leading to proliferation hemangiomas formation is poorly understood and the best approach to their management remains controversial. None of the current therapeutic modalities is ideal, partly because the pathogenesis of hemangioma and the mechanism of its proliferation are far from clear. Many clues reveal that estrogen has an important role in developing the vascular system, experimental and clinical evidences accumulated in recent years also suggest the potential for estrogen to influence neovascularization. Based on those, we hypothesize that estrogen play a potential role in the development of hemangiomas, mainly by regulating some key angiogenic factors, including MMP-9, EPCs, VEGF, NO, etc. Accepting the hypothesis to be correct, a therapy that identify estrogen as a potential target for the design of new, more specific treatments can be used to prevent the proliferation hemangiomas formation. The hypothesis may lead a new direction in the study of mechanisms for proliferation hemangiomas formation, and further study of the precise mechanisms for estogen-induced hemangiomas will produce effective antiestrogens and estrogen receptor antagonists as new medication for the very difficult problem. (C) 2008 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Sun Zhi-Yong,Yang Li,Yi Cheng-Gang, et al. Possibilities and potential roles of estrogen in the pathogenesis of proliferation hemangiomas formation [J].MEDICAL HYPOTHESES,2008,71(2):286-292.
APA：

Sun Zhi-Yong,Yang Li,Yi Cheng-Gang,Zhao Huan,&Guo Shu-Zhong.(2008).Possibilities and potential roles of estrogen in the pathogenesis of proliferation hemangiomas formation .MEDICAL HYPOTHESES,71(2):286-292.
MLA：

Sun Zhi-Yong, et al. "Possibilities and potential roles of estrogen in the pathogenesis of proliferation hemangiomas formation" .MEDICAL HYPOTHESES 71,2(2008):286-292.

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