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Computed tomography imaging-guided radiotherapy by targeting upconversion nanocubes with significant imaging and radiosensitization enhancements  期刊论文  

  • 编号:
    e7fe4d11-0913-40de-9c3c-20b7a431ec88
  • 作者:
    Xing, Huaiyong[1];Zheng, Xiangpeng[2];Ren, Qingguo[2];Bu, Wenbo[1];Ge, Weiqiang[2];Xiao, Qingfeng[1];Zhang, Shengjian(张盛箭)[3]Wei, Chenyang[1];Qu, Haiyun[1];Wang, Zheng[1];Hua, Yanqing[2];Zhou, Liangping[3];Peng, Weijun(彭卫军)[3]Zhao, Kuaile[3];Shi, Jianlin[1];
  • 语种:
    English
  • 期刊:
    SCIENTIFIC REPORTS ISSN:2045-2322 2013 年 3 卷 ; APR 29
  • 收录:
  • 摘要:

    The clinical potentials of radiotherapy could not be achieved completely because of the inaccurate positioning and inherent radioresistance of tumours. In this study, a novel active-targeting upconversion theranostic agent (arginine-glycine-aspartic acid-labelled BaYbF5:2% Er3+ nanocube) was developed for the first time to address these clinical demands. Heavy metal-based nanocubes (similar to 10 nm) are potential theranostic agents with bifunctional features: computed tomography (CT) contrast agents for targeted tumour imaging and irradiation dose enhancers in tumours during radiotherapy. Remarkably, they showed low toxicity and excellent performance in active-targeting CT imaging and CT imaging-guided radiosensitizing therapy, which could greatly concentrate and enlarge the irradiation dose deposition in tumours to enhance therapeutic efficacy and minimize the damage to surrounding tissues.

  • 推荐引用方式
    GB/T 7714:
    Xing Huaiyong,Zheng Xiangpeng,Ren Qingguo, et al. Computed tomography imaging-guided radiotherapy by targeting upconversion nanocubes with significant imaging and radiosensitization enhancements [J].SCIENTIFIC REPORTS,2013,3.
  • APA:
    Xing Huaiyong,Zheng Xiangpeng,Ren Qingguo,Bu Wenbo,&Shi Jianlin.(2013).Computed tomography imaging-guided radiotherapy by targeting upconversion nanocubes with significant imaging and radiosensitization enhancements .SCIENTIFIC REPORTS,3.
  • MLA:
    Xing Huaiyong, et al. "Computed tomography imaging-guided radiotherapy by targeting upconversion nanocubes with significant imaging and radiosensitization enhancements" .SCIENTIFIC REPORTS 3(2013).
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