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Occupational lead exposure and associations with selected cancers: The Shanghai men鈥檚 and women鈥檚 health study cohorts 期刊论文

编号：

eb5a421f-dd24-4134-aa77-e4e041a5bd33
作者：

Liao, Linda M.[0]^[1] Friesen, Melissa C.[1]^[2] Xiang, Yongbing[2]^[3] Cai, Hui[3]^[4] Koh, Donghee[4]^[5] Ji, Butian[5]^[6] Yang, Gong[6]^[7] Li, Honglan[7]^[8] Locke, Sarah J.[8]^[2] Rothman, Nathaniel[9]^[9] Zheng, Wei[10]^[10] Gao, Yutang[11]^[3] Shu, Xiaoou[12]^[7] Purdue, Mark P.H.[13]^[2]
地址：

[1]National Cancer Institute,Bethesda,United States
[2]National Cancer Institute, Department of Health and Human Services,Bethesda,United States
[3]Renji Hospital, Department of Epidemiology,Shanghai,China
[4]Arizona State University, Transport and Energy,Tempe,United States
[5]Catholic Kwandong University, Department of Occupational & Environmental Medicine,Incheon,South Korea
[6]National Cancer Institute, Division of Cancer Epidemiology and Genetics,Bethesda,United States
[7]Vanderbilt Ingram Cancer Center, Department of Medicine,Nashville,United States
[8]Medical Center of Fudan University, Department of Epidemiology,Shanghai,China
[9]National Cancer Institute, Occupational and Environmental Epidemiology Branch,Bethesda,United States
[10]VA Medical Center, Department of Medicine,,United States
Scopus被引频次：

4 次
语种：

英文
期刊：

Environmental Health Perspectives ISSN：0091-6765 2016 年 124 卷 1 期 (97 - 103)
收录：
摘要：

Background: Epidemiologic studies of occupational lead exposure have suggested increased risks of cancers of the stomach, lung, kidney, brain, and meninges; however, the totality of the evidence is inconsistent. oBjective: We investigated the relationship between occupational lead exposure and cancer incidence at the five abovementioned sites in two prospective cohorts in Shanghai, China. Methods: Annual job/industry-specific estimates of lead fume and lead dust exposure, derived from a statistical model combining expert lead intensity ratings with inspection measurements, were applied to the lifetime work histories of participants from the Shanghai Women’s Health Study (SWHS; n = 73,363) and the Shanghai Men’s Health Study (SMHS; n = 61,379) to estimate cumulative exposure to lead fume and lead dust. These metrics were then combined into an overall occupational lead exposure variable. Cohort-specific relative hazard rate ratios (RRs) and 95% confidence intervals (CIs) comparing exposed and unexposed participants were estimated using Cox proportional hazards regression and combined by meta-analysis. results: The proportions of SWHS and SMHS participants with estimated occupational lead exposure were 8.9% and 6.9%, respectively. Lead exposure was positively associated with menin-gioma risk in women only (n = 38 unexposed and 9 exposed cases; RR = 2.4; 95% CI: 1.1, 5.0), particularly with above-median cumulative exposure (RR = 3.1; 95% CI: 1.3, 7.4). However, all 12 meningioma cases among men were classified as unexposed to lead. We also observed non-significant associations with lead exposure for cancers of the kidney (n = 157 unexposed and 17 ever exposed cases; RR = 1.4; 95% CI: 0.9, 2.3) and brain (n = 67 unexposed and 10 ever exposed cases; RR = 1.8; 95% CI: 0.7, 4.8) overall. conclusions: Our findings, though limited by small numbers of cases, suggest that lead is associated with the risk of several cancers in women and men. © 2015, Public Health Services, US Dept of Health and Human Services. All rights reserved.
推荐引用方式
GB/T 7714：

Liao Linda M./46261348100[0],Friesen Melissa C./10040667000[1],Xiang Yongbing/56443305000[2], et al. Occupational lead exposure and associations with selected cancers: The Shanghai men鈥檚 and women鈥檚 health study cohorts [J].Environmental Health Perspectives,2016,124(1):97-103.
APA：

Liao Linda M./46261348100[0],Friesen Melissa C./10040667000[1],Xiang Yongbing/56443305000[2],Cai Hui/56684107000[3],&Purdue Mark P.H./6701653966[13].(2016).Occupational lead exposure and associations with selected cancers: The Shanghai men鈥檚 and women鈥檚 health study cohorts .Environmental Health Perspectives,124(1):97-103.
MLA：

Liao Linda M./46261348100[0], et al. "Occupational lead exposure and associations with selected cancers: The Shanghai men鈥檚 and women鈥檚 health study cohorts" .Environmental Health Perspectives 124,1(2016):97-103.

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