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Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3 期刊论文

编号：

ec33024b-756f-427e-981b-562c0c6e7149
作者：

Chen, ZiJiang^[1,2] Zhao, Han^[1,2] He, Lin^[3,4,5] Shi, Yuhua^[1,2] Qin, Yingying^[1,2] Shi, Yongyong^[4] Li, Zhiqiang^[4] You, Li^[1,2] Zhao, Junli^[6] Liu, Jiayin^[7] Liang, Xiaoyan^[8] Zhao, Xiaoming^[9] Zhao, Junzhao^[10] Sun, Yingpu^[11] Zhang, Bo^[12] Jiang, Hong Zhao, Dongni^[13] Bian, Yuehong^[1,2] Gao, Xuan^[1,2] Geng, Ling^[1,2] Li, Yiran^[14,15] Zhu, Dongyi^[16] Sun, Xiuqin^[17] Xu, Jine^[18] Hao, Cuifang^[19] Ren, Chune^[15] Zhang, Yajie^[20] Chen, Shiling^[21] Zhang, Wei^[22] Yang, Aijun^[23] Yan, Junhao^[1,2] Li, Yuan^[1,2] Ma, Jinlong^[1,2] Zhao, Yueran^[1,2]
语种：

English
期刊：

NATURE GENETICS ISSN：1061-4036 2011 年 43 卷 1 期 (55 - U75) ; JAN
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摘要：

Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P-meta = 7.55 x 10(-21), odds ratio (OR) 0.71); 2p21 (rs13429458, P-meta = 1.73 x 10(-23), OR 0.67); and 9q33.3 (rs2479106, P-meta = 8.12 x 10(-19), OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended.
推荐引用方式
GB/T 7714：

Chen Zi-Jiang,Zhao Han,He Lin, et al. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3 [J].NATURE GENETICS,2011,43(1):55-U75.
APA：

Chen Zi-Jiang,Zhao Han,He Lin,Shi Yuhua,&Zhao Yueran.(2011).Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3 .NATURE GENETICS,43(1):55-U75.
MLA：

Chen Zi-Jiang, et al. "Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3" .NATURE GENETICS 43,1(2011):55-U75.

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