Superparamagnetic iron-oxide nanop articles (NP) have been designed for dual modal applications include photoacoustic (PA) imaging and photothermal therapy. As the approach efficacy depends on the cellular uptake, virus-shaped nanoparticles that could potentially increase particle uptake were developed. Laser illumination could be used for both PA imaging and photo-thermally treatment of cancer. Virus-like silica encapsulated superparamagnetic iron oxide NPs were developed with a rugged surface/nanoscaffold. Nanoparticle uptake was measured in PC-3 prostate cancer cell line and NP cell uptake as a function of time and concentration were investigated. The potential application in PA imaging and photothermal therapy was shown in in-vitro experiments.
[1]Ryerson Univ, Phys Dept, Toronto, ON, Canada;
[2]Fudan Univ, State Key Lab Mol Engn Polymers, Dept Chem, Shanghai, Peoples R China;
[3]Shanghai Jiao Tong Univ, Dept Ultrasound Med, Affiliated Peoples Hosp 6, Shanghai, Peoples R China
(8.0+极速模式)