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Knocking down clock control gene CRY1 decreases adipogenesis via canonical Wnt/beta-catenin signaling pathway 期刊论文

编号：

eddb199d-b5af-4cd1-8f19-c285eba8060e
作者：

Sun, Shiwei^[1] Zhou, Lei^[1] Yu, Yueming^[1] Zhang, Tieqi^[1] Wang, Minghai^[1]
语种：

English
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2018 年 506 卷 3 期 (746 - 753) ; NOV 30
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关键词：

CRY1 Clock gene Adipogenesis Wnt beta-Catenin
摘要：

Cryptochrome gene 1(CRY1) is a member of circadian clock genes, which play an important role in adipocyte biology. CRY1 was reported to be related with the lipid metabolism, but the molecule mechanism of CRY1 in regulating the adipogenesis remains unclear. Here we report that CRY1 is a key regulator in adipogenic differentiation. We found that the expression levels of CRY1 in 3T3-L1 cells and C3H1OT1/2 cells gradually increased during the process of adipogenic differentiation. Knockdown of endogenous CRY1 significantly inhibited the expression of adipogenic markers and lipid droplet formation in cells under adipogenic induction. In addition, knockdown of endogenous CRY1 promoted the expression and nuclear accumulation of beta-catenin, the critical signal molecular in the canonical canonical Wnt signaling pathway, suggesting the regulation effect of CRY1 in adipogenesis was mediated by canonical Wnt/beta-catenin signaling. Taken together, our study suggests that CRY1 regulates adipogenic differentiation through modulating the canonical Wnt/beta-catenin signaling pathway. (C) 2018 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Sun Shiwei,Zhou Lei,Yu Yueming, et al. Knocking down clock control gene CRY1 decreases adipogenesis via canonical Wnt/beta-catenin signaling pathway [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,506(3):746-753.
APA：

Sun Shiwei,Zhou Lei,Yu Yueming,Zhang Tieqi,&Wang Minghai.(2018).Knocking down clock control gene CRY1 decreases adipogenesis via canonical Wnt/beta-catenin signaling pathway .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,506(3):746-753.
MLA：

Sun Shiwei, et al. "Knocking down clock control gene CRY1 decreases adipogenesis via canonical Wnt/beta-catenin signaling pathway" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 506,3(2018):746-753.

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