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Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs 期刊论文

编号：

edf43aaf-cf05-402a-afe1-29227c8096da
作者：

Chen, Y;Zhang, Q;Zhang, B;Xia, P(夏鹏); Xia, Y;Yang, ZY;Kilgore, N;Wild, C;MorrisNatschke, SL;Lee, KH;
语种：

English
期刊：

BIOORGANIC & MEDICINAL CHEMISTRY ISSN：0968-0896 2004 年 12 卷 24 期 (6383 - 6387) ; DEC 15
收录：
摘要：

Two thia-DCK analogs (3a,b) were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. Compound 3a showed potent anti-HIV activity with an EC50 value of 0.14 muM and a therapeutic index of 1110. However, the corresponding 6-tert-butyl-substituted compound (3b) showed no suppression. The bioassay results indicated that thia-DCK analogs merit attention as potential HIV-1 inhibitors. (C) 2004 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Chen Y,Zhang Q,Zhang B, et al. Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs [J].BIOORGANIC & MEDICINAL CHEMISTRY,2004,12(24):6383-6387.
APA：

Chen Y,Zhang Q,Zhang B,Xia P,&Lee KH.(2004).Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs .BIOORGANIC & MEDICINAL CHEMISTRY,12(24):6383-6387.
MLA：

Chen Y, et al. "Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs" .BIOORGANIC & MEDICINAL CHEMISTRY 12,24(2004):6383-6387.

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