Gliomas are the most common and deadly tumors ill the central nervous system (CNS). in the course of studying the role of chemoattractant receptors in tumor growth and metastasis, we discovered that highly malignant human glioblastoma and anaplastic astrocytoma specimens were stained positively for the formylpeptide receptor (FPR), which is normally expressed in myeloid cells and accounts for their chemotaxis and activation induced by bacterial peptides. Screening of human glioma cell lilies revealed that FPR was expressed selectively in glioma cell lilies with a more highly malignant phenotype. FPR expressed in glioblastoma cell lilies mediates cell chemotaxis. proliferation and production of all angiogenic factor. vascular endothelial growth factor (VEGF), in response to agonists released by necrotic tumor cells. Furthermore. FPR in glioblastoma cells activates the receptor for epidermal growth factor (EGFR) by increasing the phosphorylation of a selected tyrosine residue in the intracellular tail of EGFR. Thus, FPR hijacked by human glioblastoma cells exploits the function of EGFR to promote rapid tumor progression. Published by Elsevier Ltd.
[1]NCI, Ctr Canc Res, Canc & Inflammat Program, Mol Immunoregulat Lab, Frederick, MD 21702 USA.
[2]SAIC Frederick, Basic Res Program, Frederick, MD 21702 USA.
[3]Third Mil Med Univ, Southwest Hosp, Dept Pathophysiol, Chongqing, Peoples R China.
[4]Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing, Peoples R China.
[5]Fudan Univ, Canc Hosp, Shanghai 200433, Peoples R China.
[6]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China.
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