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Hypoxia-induced HMGB1 expression of HCC promotes tumor invasiveness and metastasis via regulating macrophage-derived IL-6 期刊论文

编号：

ef7210e8-acc3-48f9-a934-845f970c0876
作者：

Jiang, Jiang^[1,2];Wang, GuangZhi^[3];Wang, Ying^[3];Huang, HaoZhe^[3];Li, WenTao(李文涛)^[3]Qu, XuDong(瞿旭东)^[1,2]
语种：

English
期刊：

EXPERIMENTAL CELL RESEARCH ISSN：0014-4827 2018 年 367 卷 1 期 (81 - 88) ; JUN 1
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关键词：

Hypoxia HMGB1 Metastasis Macrophage Hepatocellular carcinoma
摘要：

Hypoxia is associated with the progression of hepatocellular carcinoma through promotion of spontaneous metastasis but the mechanism remains unclear. Here, we hypothesis that tumor cell-derived HMGB1 orchestrates macrophages infiltration and promotes metastasis of HCC via enhancing macrophage-secreted IL-6 under hypoxia. HMGB1 expression was robustly exacerbated in tumors of HCC patients with PVTT. Meanwhile, hypoxia exposure gave rise to HMGB1 expression in hepatoma cells of human and mouse in a HIF-1 alpha-dependent manner and subsequently induced the infiltration and reprogramming of macrophages to augment the expression of Il-6. Further study demonstrated macrophage-derived IL-6 enhanced the invasiveness and metastasis of murine HCC cells. Therefore, our study provides a novel understanding of the relationship between tumor cells and tumor associated macrophages (TAMs) in the context of hypoxia.
推荐引用方式
GB/T 7714：

Jiang Jiang,Wang Guang-Zhi,Wang Ying, et al. Hypoxia-induced HMGB1 expression of HCC promotes tumor invasiveness and metastasis via regulating macrophage-derived IL-6 [J].EXPERIMENTAL CELL RESEARCH,2018,367(1):81-88.
APA：

Jiang Jiang,Wang Guang-Zhi,Wang Ying,Huang Hao-Zhe,&Qu Xu-Dong.(2018).Hypoxia-induced HMGB1 expression of HCC promotes tumor invasiveness and metastasis via regulating macrophage-derived IL-6 .EXPERIMENTAL CELL RESEARCH,367(1):81-88.
MLA：

Jiang Jiang, et al. "Hypoxia-induced HMGB1 expression of HCC promotes tumor invasiveness and metastasis via regulating macrophage-derived IL-6" .EXPERIMENTAL CELL RESEARCH 367,1(2018):81-88.

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