首页 / 院系成果 / 成果详情页

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types  期刊论文  

  • 编号：
    f0b4face-790a-4273-8fa4-7872fc24ce79
  • 作者：
    Sampson, Joshua N.[1];Wheeler, William A.[2];Yeager, Meredith[3];Panagiotou, Orestis[1];Wang, Zhaoming[3];Berndt, Sonja I.[1];Lan, Qing[1];Abnet, Christian C.[1];Amundadottir, Laufey T.[1];Figueroa, Jonine D.;Landi, Maria Teresa;Mirabello, Lisa[1,244];Savage, Sharon A.[1];Taylor, Philip R.[1];De Vivo, Immaculata[4,5,6];McGlynn, Katherine A.[1];Purdue, Mark P.[7];Rajaraman, Preetha[1];Adami, HansOlov[8];Ahlbom, Anders[9];Albanes, Demetrius[1];Amary, Maria Fernanda[10,11];An, SheJuan[12];Andersson, Ulrika[13];Andriole, Gerald, Jr.[14];Andrulis, Irene L.[15,16];Angelucci, Emanuele[17];Ansell, Stephen M.[18];Arici, Cecilia[19];Armstrong, Bruce K.[20];Arslan, Alan A.[21,22,23,24];Austin, Melissa A.[25];Baris, Dalsu;Barkauskas, Donald A.[26];Bassig, Bryan A.[1,27];Becker, Nikolaus;Benavente, Yolanda[28,29];Benhamou, Simone[30,31];Berg, Christine[32];Van Den Berg, David[26,33];Bernstein, Leslie[34];Bertrand, Kimberly A.[4,5,6];Birmann, Brenda M.[4,5];Black, Amanda[1];Boeing, Heiner[35];Boffetta, Paolo[36];BoutronRuault, MarieChristine[38,39];Bracci, Paige M.[40];Brinton, Louise[1];BrooksWilson, Angela R.[41,42];BuenodeMesquita, H. Bas[43,44];Burdett, Laurie[3];Buring, Julie[45,46,47,48];Butler, Mary Ann[49];Cai, Qiuyin[50,51];CancelTassin, Geraldine[52,53];Canzian, Federico[54];Carrato, Alfredo[55];Carreon, Tania[49];Carta, Angela[19];Chan, John K. C.[56];Chang, Ellen T.[57,58];Chang, GeeChen[59,60];Chang, IShou[61];Chang, Jiang[62,63];ChangClaude, Jenny;Chen, ChienJen[64];Chen, ChihYi[65];Chen, Chu[66,67];Chen, ChungHsing[61];Chen, Constance[4,5,6];Chen, Hongyan[68];Chen, Kexin[69];Chen, KuanYu[70];Chen, KunChieh[60];Chen, Ying[71];Chen, YingHsiang[72];Chen, YiSong[72];Chen, YuhMin[73,74];Chien, LiHsin[72];Chirlaque, MariaDolores[29,75];Choi, Jin Eun[76];Choi, Yi Young[76];Chow, WongHo[1];Chung, Charles C.[1];Clavel, Jacqueline[38,77];ClavelChapelon, Franoise[37,38,39];Cocco, Pierluigi[78];Colt, Joanne S.[1];Comperat, Eva[52,53,79,80];Conde, Lucia[81,82,83,84];Connors, Joseph M.[85];Conti, David[26,33];Cortessis, Victoria K.[26,33,86];Cotterchio, Michelle[87,88];Cozen, Wendy[26,33];Crouch, Simon[89];CrousBou, Marta[4,5,6];Cussenot, Olivier[52,53,90];Davis, Faith G.[91];Ding, Ti[92];Diver, W. Ryan[93];Dorronsoro, Miren[29,94];Dossus, Laure[37,38,39];Duell, Eric J.[95];Ennas, Maria Grazia[96];Erickson, Ralph L.[97];Feychting, Maria[9];Flanagan, Adrienne M.[10,11];Foretova, Lenka[98,99];Fraumeni, Joseph F., Jr.[1];Freedman, Neal D.[1];Freeman, Laura E. Beane[1];Fuchs, Charles[4,5,100];GagoDominguez, Manuela[101];Gallinger, Steven[16];Gao, YuTang[102];Gapstur, Susan M.[93];GarciaClosas, Montserrat[1,103];GarciaClosas, Reina[104];Gascoyne, Randy D.[105];GastierFoster, Julie[106,107];Gaudet, Mia M.[93];Gaziano, J. Michael[45,46,47,48,108];Giffen, Carol[2];Giles, Graham G.[109,110];Giovannucci, Edward[4,5,6,67];Glimelius, Bengt[111,112];Goggins, Michael[113,114,115,116];Gokgoz, Nalan[15,16];Goldstein, Alisa M.[1];Gorlick, Richard[117];Gross, Myron[118];Grubb, Robert, III[14];Gu, Jian[119];Guan, Peng[120];Gunter, Marc[121];Guo, Huan[122,123];Habermann, Thomas M.[18];Haiman, Christopher A.;Halai, Dina[10,11];Hallmans, Goran[124];Hassan, Manal[125];Hattinger, Claudia;He, Qincheng[120];He, Xingzhou[127];Helzlsouer, Kathy[128];Henderson, Brian[26];Henriksson, Roger[13];Hjalgrim, Henrik[129];HoffmanBolton, Judith[128];Hohensee, Chancellor[66];Holford, Theodore R.[130];Holly, Elizabeth A.[40];Hong, YunChul[131];Hoover, Robert N.[1];HornRoss, Pamela L.[132];Hosain, G. M. Monawar[133];Hosgood, H. Dean, III[134];Hsiao, ChinFu[72,135];Hu, Nan[1];Hu, Wei[1];Hu, Zhibin[136,137];Huang, MingShyan[138];Huerta, JoseMaria[75];Hung, JenYu[138];Hutchinson, Amy[3];Inskip, Peter D.[1];Jackson, Rebecca D.[139];Jacobs, Eric J.[93];Jenab, Mazda[140];Jeon, HyoSung[141];Ji, BuTian[1];Jin, Guangfu[136,137];Jin, Li(金力)[68]Johansen, Christoffer[142];Johnson, Alison[143];Jung, Yoo Jin[144];Kaaks, Rudolph;Kamineni, Aruna[145];Kane, Eleanor[89];Kang, Chang Hyun[144];Karagas, Margaret R.[146];Kelly, Rachel S.[6,147];Khaw, KayTee[148];Kim, Christopher;Kim, Hee Nam[149];Kim, Jin Hee[150];Kim, Jun Suk[151];Kim, Yeul Hong[152];Kim, Young Tae[144];Kim, YoungChul[153,154];Kitahara, Cari M.[1];Klein, Alison P.[128,155];Klein, Robert J.[156];Kogevinas, Manolis[157,158,159];Kohno, Takashi[160];Kolonel, Laurence N.[161];Kooperberg, Charles;Kricker, Anne[20];Krogh, Vittorio[162];Kunitoh, Hideo[163];Kurtz, Robert C.[164];Kweon, SunSeog[165,166];LaCroix, Andrea;Lawrence, Charles[167];Lecanda, Fernando[168];Lee, Victor Ho Fun[169];Li, Donghui[125];Li, Haixin[69];Li, Jihua;Li, YaoJen[64];Li, Yuqing[132];Liao, Linda M.[1];Liebow, Mark[18];Lightfoot, Tracy[89];Lim, WeiYen[71];Lin, ChienChung[171];Lin, Dongxin[62,63];Lindstrom, Sara[4,5,6];Linet, Martha S.[1];Link, Brian K.;Liu, Chenwei[3];Liu, Jianjun[170,173];Liu, Li[174];Ljungberg, Boerje;Lloreta, Josep[29];Di Lollo, Simonetta;Lu, Daru[68];Lund, Eiluv[175];Malats, Nuria;Mannisto, Satu[176];Le Marchand, Loic[177];Marina, Neyssa;Masala, Giovanna[178];Mastrangelo, Giuseppe[179];Matsuo, Keitaro[180];Maynadie, Marc[181,182];Mckay, James[140];McKeanCowdin, Roberta[26];Melbye, Mads[129,183];Melin, Beatrice S.[13];Michaud, Dominique S.;Mitsudomi, Tetsuya[185];Monnereau, Alain[38,77,186];Montalvan, Rebecca[167];Moore, Lee E.[1];Mortensen, Lotte Maxild;Nieters, Alexandra[187];North, Kari E.[188,189];Novak, Anne J.[18];Oberg, Ann L.[190];Offit, Kenneth[164];Oh, InJae[153,154];Olson, Sara H.[191];Palli, Domenico[178];Pao, William[192];Park, In Kyu[144];Park, Jae Yong[193];Park, Kyong Hwa[152];PatinoGarcia, Ana[168];Pavanello, Sofia[179];Peeters, Petra H. M.[121,194,195];Perng, ReuryPerng[73];Peters, Ulrike;Petersen, Gloria M.[196];Picci, Piero[126];Pike, Malcolm C.[191];Porru, Stefano[19];Prescott, Jennifer[4,5,6];ProkuninaOlsson, Ludmila[1];Qian, Biyun[197];Qiao, YouLin[198];Rais, Marco[78];Riboli, Elio[89,184];Riby, Jacques[81,82,83,84];Risch, Harvey A.[199];Rizzato, Cosmeri[54];Rodabough, Rebecca;Roman, Eve;Roupret, Morgan[52,53,79];Ruder, Avima M.[49];de Sanjose, Silvia[28];Scelo, Ghislaine[140];Schned, Alan[146];Schumacher, Fredrick[26];Schwartz, Kendra[126];Schwenn, Molly[201];Scotlandi, Katia;Seow, Adeline[71];Serra, Consol[202];Serra, Massimo[126];Sesso, Howard D.[6,45,46,47,48];Setiawan, Veronica Wendy[26];Severi, Gianluca[109,110,203];Severson, Richard K.[200];Shanafelt, Tait D.[18];Shen, Hongbing[136,137];Shen, Wei[136,137];Shin, MinHo[166];Shiraishi, Kouya;Shu, XiaoOu[50,51];Siddiq, Afshan[184];Sierrasesumaga, Luis[168];Sihoe, Alan Dart Loon[204];Skibola, Christine F.[81,82,83,84];Smith, Alex[89];Smith, Martyn T.[83,84];Southey, Melissa C.;Spinelli, John J.[205,206];Staines, Anthony[207];Stampfer, Meir[4,5,6,67];Stern, Marianna C.;Stevens, Victoria L.[93];StolzenbergSolomon, Rachael S.[1];Su, Jian[12];Su, WuChou[208];Sund, Malin[209];Sung, Jae Sook[210];Sung, Sook Whan[211];Tan, Wen[62,63];Tang, Wei[1];Tardon, Adonina[29,212];Thomas, David[213];Thompson, Carrie A.[18];Tinker, Lesley F.;Tirabosco, Roberto[11];Tjonneland, Anne[214];Travis, Ruth C.[215];Trichopoulos, Dimitrios[6,216,217];Tsai, FangYu[61];Tsai, YingHuang[218];Tucker, Margaret[1];Turner, Jenny[219,220];Vajdic, Claire M.[221];Vermeulen, Roel C. H.[194,222];Villano, Danylo J.[164];Vineis, Paolo[147,203];Virtamo, Jarmo[164,176];Visvanathan, Kala[128];WactawskiWende, Jean[120,223];Wang, Chaoyu[1];Wang, ChihLiang[224];Wang, JiuCun[68,225];Wang, Junwen[226,227];Wei, Fusheng[228];Weiderpass, Elisabete[8,175,229,230];Weiner, George J.[172];Weinstein, Stephanie[1];Wentzensen, Nicolas[1];White, Emily[25];Witzig, Thomas E.[18];Wolpin, Brian M.[100,231,46];Wong, Maria Pik[232];Wu, Chen[62,63,233];Wu, Guoping[228];Wu, Junjie[68];Wu, Tangchun[122,123];Wu, Wei;Wu, Xifeng[119];Wu, YiLong[12];Wunder, Jay S.[15,16];Xiang, YongBing[234];Xu, Jun[235];Xu, Ping[236];Yang, PanChyr[237];Yang, TsungYing[60];Ye, Yuanqing[119];Yin, Zhihua[120];Yokota, Jun[238];Yoon, HoIl[239];Yu, ChongJen[70];Yu, Herbert[177];Yu, Kai[1];Yuan, JianMin[240];Zelenetz, Andrew[22,23,24,164];ZeleniuchJacquotte, Anne;Zhang, XuChao[12];Zhang, Yawei[27];Zhao, Xueying[68];Zhao, Zhenhong[68];Zheng, Hong[69];Zheng, Tongzhang[27];Zheng, Wei[50,51];Zhou, Baosen[120];Zhu, Meng;Zucca, Mariagrazia;Boca, Simina M.;Cerhan, James R.[241];Ferri, Giovanni M.[242];Hartge, Patricia[1];Hsiung, Chao Agnes;Magnani, Corrado[243];Miligi, Lucia;Morton, Lindsay M.;Smedby, Karin E.[245];Teras, Lauren R.;Vijai, Joseph;Wang, Sophia S.[34];Brennan, Paul[140];Caporaso, Neil E.[1];Hunter, David J.[4,5,6,67,246,247];Kraft, Peter[6,248];Rothman, Nathaniel[1];Silverman, Debra T.[1];Slager, Susan L.[241];Chanock, Stephen J.[1];Chatterjee, Nilanjan[1];
  • 语种：
    英文
  • 期刊：
    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE ISSN：0027-8874 2015 年 107 卷 12 期 ; DEC
  • 收录：
     
  • 摘要：

    Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.
    Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.
    Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.
    Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

  • 推荐引用方式
    GB/T 7714：
    Sampson Joshua N.,Wheeler William A.,Yeager Meredith, et al. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types [J].JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE,2015,107(12).
  • APA：
    Sampson Joshua N.,Wheeler William A.,Yeager Meredith,Panagiotou Orestis,&Chatterjee Nilanjan.(2015).Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types .JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE,107(12).
  • MLA：
    Sampson Joshua N., et al. "Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types" .JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 107,12(2015).
  • 条目包含文件：
    文件类型：PDF,文件大小：
    正在加载全文
浏览次数：47 下载次数：0
分享到：
浏览次数：47
下载次数：0
打印次数：0

网站总浏览量： 次   

Copyright © 复旦大学上海医学院机构知识仓储平台

技术支持：北京同舟云网络信息技术有限公司

浏览器支持: Google Chrome   火狐   360浏览器极速模式(8.0+极速模式) 
返回顶部