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On-treatment changes of liver stiffness at week 26 could predict 2-year clinical outcomes in HBV-related compensated cirrhosis 期刊论文

编号：

f1571548-89ee-4a7a-b3ea-370c13d1ba58
作者：

Wu, Shanshan^[1];Kong, Yuanyuan^[1];Piao, Hongxin^[2];Jiang, Wei(蒋炜)^[3]Xie, Wen^[4];Chen, Yongpeng^[5];Lu, Lungen^[6];Ma, Anlin^[7];Xie, Shibin^[8];Ding, Huiguo^[9];Shang, Jia^[10];Zhang, Xuqing^[11];Feng, Bo^[12];Han, Tao^[13];Xu, Xiaoyuan^[14];Huo, Lijuan^[15];Cheng, Jilin(程计林)^[16]Li, Hai^[17];Wu, Xiaoning^[1];Zhou, Jialing^[1];Sun, Yameng^[1];Ou, Xiaojuan^[1];Zhang, Hui^[18];You, Hong^[1];Jia, Jidong^[1];
语种：

英文
期刊：

LIVER INTERNATIONAL ISSN：1478-3223 2018 年 38 卷 6 期 (1045 - 1054) ; JUN
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关键词：

dynamic change HBV-related compensated cirrhosis liver-related events liver stiffness
摘要：

Background & AimsIt is unclear whether liver stiffness measurement (LSM) dynamic changes after anti-HBV treatment could predict the risk of liver-related events (LREs), particularly in patients with HBV-related compensated cirrhosis.
MethodsTreatment-naive patients with HBV-related compensated cirrhosis were enrolled. All patients were under entecavir-based antiviral therapy, and followed up every 26weeks for 2years. The association between LSM and LREs was analysed by Cox proportional hazard model and Harrell C-index analysis.
ResultsA total of 438 patients were included in the study. At the follow-up of 104weeks, LREs developed in 33/438 (7.8%) patients, including 16 episodes of decompensation, 18 HCC and 3 deaths. The median LSM remained high from 20.9, 18.6, 20.4 to 20.3Kpa at week 0, 26, 52 and 78 among patients with LREs, whereas the LSM decreased from 17.8, 12.3, 10.6 to 10.2Kpa in patients without LREs respectively. Percentage changes of LSM at 26weeks from baseline were significantly associated with LREs (excluding 11 cases occurred within the first 26weeks), with a crude hazard ratio of 2.94 (95% CI: 1.73-5.00) and an albumin-adjusted hazard ratio of 2.47 (95% CI: 1.49-4.11). The Harrell C-index of these 2 models for predicting 2-year LREs were 0.68 (95% CI: 0.56-0.80) and 0.75 (95% CI: 0.65-0.85) respectively. Nomograms were developed to identify individuals at high risk for point-of-care application.
ConclusionsDynamic changes of LSM alone, or combined with baseline albumin, could predict LREs in patients with HBV-related compensated cirrhosis during antiviral therapy.
推荐引用方式
GB/T 7714：

Wu Shanshan,Kong Yuanyuan,Piao Hongxin, et al. On-treatment changes of liver stiffness at week 26 could predict 2-year clinical outcomes in HBV-related compensated cirrhosis [J].LIVER INTERNATIONAL,2018,38(6):1045-1054.
APA：

Wu Shanshan,Kong Yuanyuan,Piao Hongxin,Jiang Wei,&Jia Jidong.(2018).On-treatment changes of liver stiffness at week 26 could predict 2-year clinical outcomes in HBV-related compensated cirrhosis .LIVER INTERNATIONAL,38(6):1045-1054.
MLA：

Wu Shanshan, et al. "On-treatment changes of liver stiffness at week 26 could predict 2-year clinical outcomes in HBV-related compensated cirrhosis" .LIVER INTERNATIONAL 38,6(2018):1045-1054.
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