首页 / 院系成果 / 成果详情页

Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells 期刊论文

编号：

f2c0b15b-b828-4ef4-a291-c38721aed1b2
作者：

Wang, Yu(王宇)^[1,2]Bi, Yujing^[3];Chen, Xi^[1,2];Li, Chunxiao^[1,2];Li, Yan^[1,2];Zhang, Zhengguo^[1,2];Wang, Jian^[1,2];Lu, Yun(陆芸)^[1,2]Yu, Qing^[1];Su, Huilin^[1,2];Yang, Hui(杨慧)^[2]Liu, Guangwei(刘光伟)*^[1,2]
语种：

English
期刊：

IMMUNITY ISSN：1074-7613 2016 年 44 卷 6 期 (1337 - 1349) ; JUN 21
收录：
摘要：

Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase SIRT1 negatively regulated Th9 cell differentiation. A deficiency of SIRT1 induced by either conditional deletion in mouse CD4(+) T cells or the use of small interfering RNA (siRNA) in mouse or human T cells increased IL-9 production, whereas ectopic SIRT1 expression inhibited it. Notably, SIRT1 inhibited Th9 cell differentiation that regulated anti-tumor immunity and allergic pulmonary inflammation. Glycolytic activation through them TOR-hypoxia- inducible factor-1 alpha (HIF1 alpha) was required for the differentiation of Th9 cells that conferred protection against tumors and is involved in allergic airway inflammation. Our results define the essential features of SIRT1-mTOR-HIF1 alpha signaling-coupled glycolytic pathway in inducing Th9 cell differentiation, with implications for metabolic reprogramming as an immunotherapeutic approach.
推荐引用方式
GB/T 7714：

Wang Yu,Bi Yujing,Chen Xi, et al. Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells [J].IMMUNITY,2016,44(6):1337-1349.
APA：

Wang Yu,Bi Yujing,Chen Xi,Li Chunxiao,&Liu Guangwei.(2016).Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells .IMMUNITY,44(6):1337-1349.
MLA：

Wang Yu, et al. "Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells" .IMMUNITY 44,6(2016):1337-1349.

浏览次数：3  下载次数：0

分享到：

浏览次数：3

下载次数：0

打印次数：0