Recent advances in the metal-catalyzed radical-type transformation of unactivated alkyl halides with C-C bond formation under photoinduced conditions are summarized. In general, an alkyl radical is generated as the key intermediate under visible light irradiation from unactivated alkyl halides. Different metal catalysts including Pd, Cu, Mn, Au, and Ir are reported to promote the conversion effectively. Additionally, a strategy by merging photoredox and transition metal catalysis is successfully applied in the cross-electrophile coupling of alkyl halides. During the reaction process, the undesired beta-hydride elimination is suppressed. Usually, a broad reaction scope is observed, including tertiary, secondary, and primary alkyl halides, with good functional group compatibility.
[1]Taizhou Univ, Sch Pharmaceut & Chem Engn, 1139 Shifu Ave, Taizhou 318000, Peoples R China;
[2]Shenyang Pharmaceut Univ, Coll Pharm, 106 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China;
[3]Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China; Fudan Univ, Dept Chem, 2005 Songhu Rd, Shanghai 200438, Peoples R China
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