Background and purpose: The aim of the present study was to investigate the role of three hypoxia-related biomarkers in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated with concurrent chemoradiotherapy (3-weekly cisplatin) or bioradiotherapy (weekly cetuximab). Material and methods: In tumor tissue material from 100 patients with known HPV status, we evaluated the extent of tumor necrosis, the expression level of CA-IX and the microvascular density (MVD) measured as the density of CD34+ vascular structures. The correlations between biomarker expressions and clinicopathological characteristics and treatment outcomes were analyzed. Results: We found a significant correlation of MVD with UICC stage (p = 0.02) and T classification (p = 0.05), of CA-IX with UICC stage (p = 0.03) and N classification (p = 0.04) and a significant inverse correlation of MVD with CA-IX expression (r = -0.22, p = 0.03). Multivariate analysis showed that low MVD combined with high CA IX-expression was a significant independent prognostic factor for worse loco regional control (HR = 2.6, 95%Cl 1.1-5.0, p = 0.02) in the whole population but not in the p16+ subgroup. Patients treated with CRT had a better LRC than those with BRT independent of MVD or CA-IX expression. Conclusions: The combination of MVD and CA-IX expression might give additional prognostic information in HNSCC patients with known HPV status. (C) 2017 Elsevier B.V. All rights reserved.
[1]Paris Saclay Univ, Dept Radiat Oncol, Gustave Roussy, 114 Rue Edouard, F-94805 Villejuif, France;
[2]Fudan Univ, Shanghai Canc Ctr, Dept Radiat Oncol, Shanghai, Peoples R China;
[3]Paris Saclay Univ, Gustave Roussy, Dept Pathol, Villejuif, France;
[4]Paris Saclay Univ, Gustave Roussy, Dept Head & Neck Oncol, Villejuif, France
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