首页 / 院系成果 / 成果详情页

Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression 期刊论文

编号：

f65379ea-f9c4-4ee1-9e60-af27a929abcc
作者：

Han, Yanmei^[1,2];Liu, Qiuyan^[1,2];Hou, Jin^[1,2];Gu, Yan^[1,2];Zhang, Yi^[1,2];Chen, Zhubo^[3,4];Fan, Jia(樊嘉)^[5]Zhou, Weiping^[6];Qiu, Shuangjian(邱双健)^[5]Zhang, Yonghong^[3,4,7];Dong, Tao^[3,4,7];Li, Ning^[3,4,7];Jiang, Zhengping^[1,2];Zhu, Ha^[1,2];Zhang, Qian^[1,2];Ma, Yuanwu^[8];Zhang, Lianfeng^[8];Wang, Qingqing^[9];Yu, Yizhi^[1,2];Li, Nan^[1,2];Cao, Xuetao^[1,2,3,4,10];
语种：

English
期刊：

CELL ISSN：0092-8674 2018 年 173 卷 3 期 (634 - +) ; APR 19
收录：
摘要：

Identifying tumor-induced leukocyte subsets and their derived circulating factors has been instrumental in understanding cancer as a systemic disease. Nevertheless, howprimary tumor-induced non-leukocyte populations in distal organs contribute to systemic spread remains poorly defined. Here, we report one population of tumor-inducible, erythroblast-like cells (Ter-cells) deriving from megakaryocyte-erythroid progenitor cells with a unique Ter-119(+)CD45(-)CD71(+) phenotype. Ter-cells are enriched in the enlarged spleen of hosts bearing advanced tumors and facilitate tumor progression by secreting neurotrophic factor arteminintothe blood. Transforming growth factor beta (TGF-beta) and Smad3 activation are important in Ter-cell generation. In vivo blockade of Ter-cell-derived artemin inhibits hepatocellular carcinoma (HCC) growth, and artemin deficiency abolishes Ter-cells' tumor-promoting ability. We confirm the presence of splenic artemin-positive Ter-cells in human HCC patients and show that significantly elevated serum artemin correlates with poor prognosis. We propose that Ter-cells and the secreted artemin play important roles in cancer progression with prognostic and therapeutic implications.
推荐引用方式
GB/T 7714：

Han Yanmei,Liu Qiuyan,Hou Jin, et al. Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression [J].CELL,2018,173(3):634-+.
APA：

Han Yanmei,Liu Qiuyan,Hou Jin,Gu Yan,&Cao Xuetao.(2018).Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression .CELL,173(3):634-+.
MLA：

Han Yanmei, et al. "Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression" .CELL 173,3(2018):634-+.

浏览次数：22  下载次数：0

分享到：

浏览次数：22

下载次数：0

打印次数：0