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Long-term survival and late complications of intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma 期刊论文

编号：

f67ebc0b-d925-4c48-86a5-72e0d06d43ec
作者：

Kong, Fangfang(孔芳芳)#^[1,2]Zhou, Junjun^[1,2,3];Du, Chengrun^[1,2];He, Xiayun(何霞云)^[1,2]Kong, Lin(孔琳)^[1,2,4]Hu, Chaosu(胡超苏)^[1,2]Ying, Hongmei(应红梅)*^[1,2]
语种：

英文
期刊：

BMC CANCER ISSN：1471-2407 2018 年 18 卷 ; NOV 20
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关键词：

Intensity-modulated radiotherapy IMRT Recurrent nasopharyngeal carcinoma NPC Re-irradiation Survival Late complication
摘要：

To evaluate the effectiveness and toxicities of intensity-modulated radiotherapy (IMRT) for locally recurrent nasopharyngeal carcinoma (NPC).
One hundred and eighty-four previously irradiated NPC patients with recurrent disease and re-irradiated by IMRT between February 2005 to May 2013 had been reviewed. The disease was re-staged I in 33, II in 27, III in 70 and IV in 54 patients. Seventy-five percent of the patients received cisplatin-based chemotherapy.
The median survival time was 33 months. The 3-year actuarial rates of local recurrence-free survival (LRFS), distant metastases-free survival (DMFS), and overall survival (OS) rates were 85.1, 91.1, and 46.0%, respectively. About 53% of the patients experienced Grade 3-4 late toxicities. Forty-four patients died of massive hemorrhage of the nasopharynx caused by radiation induced mucosal necrosis. Multivariate analysis indicated that chemotherapy and time interval between initial radiotherapy and re-irradiation were independent predictors for DMFS.
IMRT is an effective method for patients with locally recurrent NPC. Massive hemorrhage of the nasopharynx is the major sever late complication and also the leading cause of death. Early recurrence is negative factor for DMFS. Combination of chemotherapy can improve DMFS, but not for OS. Optimal salvage treatment strategies focusing on improvement of survival and minimization of late toxicities are warranted.
推荐引用方式
GB/T 7714：

Kong Fangfang,Zhou Junjun,Du Chengrun, et al. Long-term survival and late complications of intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma [J].BMC CANCER,2018,18.
APA：

Kong Fangfang,Zhou Junjun,Du Chengrun,He Xiayun,&Ying Hongmei.(2018).Long-term survival and late complications of intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma .BMC CANCER,18.
MLA：

Kong Fangfang, et al. "Long-term survival and late complications of intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma" .BMC CANCER 18(2018).
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