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In situ intestinal absorption of cyclosporine a solid dispersion in rats 期刊论文

编号：

f81dc629-1784-4191-9bfa-42810d404a2e
作者：

Liu, Chen(柳晨)#^[1]Zhu, Saijie^[1];Zhou, Ying^[1];Wei, Yupu^[1];Pei, Yuanying(裴元英)*^[1]
语种：

English
期刊：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY ISSN：0363-9045 2008 年 34 卷 6 期 (627 - 631)
收录：
关键词：

cyclosporine A solid dispersion polyoxyethylene (40) stearate in situ circulation absorption behavior
摘要：

Effects of concentration of Polyoxyethylene (40) stearate, Na+ and P-gp inhibitor on cyclosporin A (CyA-SD) absorption were investigated by in situ circulation method. The results showed that the absorption of CyA increased linearly with its concentration, indicating a passive diffusion process was dominated. CyA absorption decreased with the carrier concentration. The concentration of Na+ didn't influence the drug absorbed (P > 0.05). The P-gp inhibitor enhanced the CyA absorption significantly (P < 0.05). The passive diffusion process during the intestinal absorption indicated that the solubility enhancement of CyA is one of the mechanisms for the absorption of this water insoluble drug.
推荐引用方式
GB/T 7714：

Liu Chen,Zhu Saijie,Zhou Ying, et al. In situ intestinal absorption of cyclosporine a solid dispersion in rats [J].DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2008,34(6):627-631.
APA：

Liu Chen,Zhu Saijie,Zhou Ying,Wei Yupu,&Pei Yuanying.(2008).In situ intestinal absorption of cyclosporine a solid dispersion in rats .DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,34(6):627-631.
MLA：

Liu Chen, et al. "In situ intestinal absorption of cyclosporine a solid dispersion in rats" .DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 34,6(2008):627-631.

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