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Cancer-Targeting Graphene Quantum Dots: Fluorescence Quantum Yields, Stability, and Cell Selectivity 期刊论文

编号：

f86417ee-a27f-4602-bb25-be59d9c06755
作者：

Zhang, Qing^[1] Deng, Sinan^[2] Liu, Jinlin^[3] Zhong, Xiaoxia^[1] He, Jie^[4,5] Chen, Xianfeng^[1] Feng, Bowen^[1] Chen, Yanfei^[1] Ostrikov, Kostya (Ken)^[6,7]
语种：

英文
期刊：

ADVANCED FUNCTIONAL MATERIALS ISSN：1616-301X 2019 年 29 卷 5 期 ; FEB 1
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关键词：

cancer folate receptors folic acid graphene quantum dots luminescence
摘要：

Folic acid, due to its high affinity toward folate receptors (FR), is recognized as one of the most promising cancer targeting vectors. However, the inherent defects of low water solubility (1.6 mu g mL(-1)), high sensitivity toward photo-bleaching, low fluorescent quantum yields (QYs, <0.5%) seriously limit its practical application. Herein, ultrastable, highly luminescent graphene quantum dots (GQDs) that selectively target diverse cancer cells are prepared and tested. The new GQDs present step changes compared to common folic acid through an approximate to 6250 times increase in water solubility (to approximate to 10 mg mL(-1)), more than 150 times in QYs (up to approximate to 77%), while maintaining luminescence stability up to 98% when subjected to UV, visible light, and heating over 360 min. It is shown that the suppression of nonradiative transitions by amino groups pyrolyzed from pterin plays a key role in the mechanism of high QYs and excellent stability. The functional groups that are likely responsible for the selective targeting of cancer cells with different levels of folate receptor expression on the surface are identified. Collectively with these promising properties, the new functional graphene quantum dots may open a new avenue for cancer diagnosis, drug delivery, and therapies.
推荐引用方式
GB/T 7714：

Zhang Qing,Deng Sinan,Liu Jinlin, et al. Cancer-Targeting Graphene Quantum Dots: Fluorescence Quantum Yields, Stability, and Cell Selectivity [J].ADVANCED FUNCTIONAL MATERIALS,2019,29(5).
APA：

Zhang Qing,Deng Sinan,Liu Jinlin,Zhong Xiaoxia,&Ostrikov Kostya (Ken).(2019).Cancer-Targeting Graphene Quantum Dots: Fluorescence Quantum Yields, Stability, and Cell Selectivity .ADVANCED FUNCTIONAL MATERIALS,29(5).
MLA：

Zhang Qing, et al. "Cancer-Targeting Graphene Quantum Dots: Fluorescence Quantum Yields, Stability, and Cell Selectivity" .ADVANCED FUNCTIONAL MATERIALS 29,5(2019).

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