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Prokineticin 2 is involved in the thermoregulation and energy expenditure 期刊论文

编号：

f8bf3e92-8872-418d-98a0-b5466bd482c0
作者：

Zhou, Wenbai(周闻白)^[2,3]Li, JiaDa^[1,2];Hu, WangPing^[2,4];Cheng, Michelle Y.^[2];Zhou, QunYong^[2];
语种：

English
期刊：

REGULATORY PEPTIDES ISSN：0167-0115 2012 年 179 卷 1-3 期 (84 - 90) ; NOV 10
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关键词：

Prokineticin 2 Torpor Fasting Arousal
摘要：

Animals have developed adaptive strategies to survive tough situations such as food shortage. However, the underlying molecular mechanism is not fully understood. Here, we provided evidence that the regulatory peptide prokineticin 2 (PK2) played an important role in such an adaptation. The PK2 expression was rapidly induced in the hypothalamic paraventricular nucleus (PVN) after fasting, which can be mimicked by 2-deoxy-D-glucose (2-DG) injection. The fasting-induced arousal was absent in the PK2-deficient (PK2(-/-)) mice. Furthermore, PK2(-/-) mice showed less energy expenditure and body weight loss than wild-type (WT) controls upon fasting. As a result. PK2(-/-) mice entered torpor after fasting. Supply of limited food (equal to 5% of body weight) daily during fasting rescued the body weight loss and hypothermal phenotype in WT mice, but not in PK2(-/-) mice. Our study thus demonstrated PK2 as a regulator in the thermoregulation and energy expenditure. (C) 2012 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Zhou Wenbai,Li Jia-Da,Hu Wang-Ping, et al. Prokineticin 2 is involved in the thermoregulation and energy expenditure [J].REGULATORY PEPTIDES,2012,179(1-3):84-90.
APA：

Zhou Wenbai,Li Jia-Da,Hu Wang-Ping,Cheng Michelle Y.,&Zhou Qun-Yong.(2012).Prokineticin 2 is involved in the thermoregulation and energy expenditure .REGULATORY PEPTIDES,179(1-3):84-90.
MLA：

Zhou Wenbai, et al. "Prokineticin 2 is involved in the thermoregulation and energy expenditure" .REGULATORY PEPTIDES 179,1-3(2012):84-90.

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